DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment F2RL1 and TkR86C

DIOPT Version :9

Sequence 1:	NP_005233.4	Gene:	F2RL1 / 2150	HGNCID:	3538	Length:	397	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	93/428 - (21%)
Similarity:	185/428 - (43%)	Gaps:	51/428 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     9 LLGAAILLAASLSCSGTIQGTSRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKL 73
            |:...||.......:..:..|...|..|:.:  |...|.:......:|::....:|....|....
  Fly    10 LVNCTILAVRRFELNSIVNTTLLGSLNRTEV--VSLLSSIIDNRDNLESINEAKDFLTECLFPSP 72

Human    74 TTVF-LP--------IVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFP 129
            |..: ||        |::.::..|.:..||:.||:.......:.....::.||::||||   ...
  Fly    73 TRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLL---MSS 134

Human   130 LKIAYH---IHGNNWIYGEALCNVLIGFFYGN--MYCSILFMTCLSVQRYWVIVNPMGH--SRKK 187
            |...::   :..::|.:|...|.  |..|..|  :..|:..:..:|..||..||:|:..  ||:|
  Fly   135 LNCVFNFIFMLNSDWPFGSIYCT--INNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRK 197

Human   188 ANIAIGISLAIWLLILLVTIPLYVVKQTI---FIPALNITTCHDVLPEQLLVGDMFNYFLSLAIG 249
            ..|   |.:.||.|..:::.|..:....:   :....:.|.|..:.|:......|.:|..:|.|.
  Fly   198 VRI---ILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIIL 259

Human   250 VFLF--PAFLTASAYVLMIRML-RSSAMDENSE------KKRKRAIKLIVTVLAMYLICFTPSNL 305
            |..:  |..:....|.||.|:| .|.::.||::      |.:::.:::.:.:::::.||:.|.:|
  Fly   260 VLTYGIPMIVMLICYSLMGRVLWGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHL 324

Human   306 LLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQM 370
            ..:..|...:.....:|..:|:....|:..|:.::|.:||:::..||.:.:..:.|..|...:..
  Fly   325 FFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHR 389

Human   371 ----QVSLTSK----KHSR-----KSSSYSSSSTTVKT 395
                :..||:|    :|:|     ..|..:||..|.:|
  Fly   390 FDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPTTQT 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
F2RL1	NP_005233.4	7tmA_PAR2	76..355	CDD:320492	69/306 (23%)
		TM helix 1	76..103	CDD:320492	8/35 (23%)
		TM helix 2	110..135	CDD:320492	7/24 (29%)
		TM helix 3	148..178	CDD:320492	8/31 (26%)
		TM helix 4	189..211	CDD:320492	6/21 (29%)
		TM helix 5	239..268	CDD:320492	9/30 (30%)
		TM helix 6	280..310	CDD:320492	5/29 (17%)
		TM helix 7	323..348	CDD:320492	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..397		10/32 (31%)
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	66/291 (23%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	61/270 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910