Protein Alignment ABCD1 and PXA1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_015178.1
• Gene: PXA1 / 855956
• SGDID: S000006068
• Length: 870
• Species: Saccharomyces cerevisiae
• Alignment Length: 796
• Identity: 246/796 - (30%)
• Similarity: 395/796 - (49%)
• Gaps: 158/796 - (19%)

Human    71 FLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLL 135
            ||.::..|.::|.|.|..:...||......||.||:||::||:|||::.:.|:....|:|.|.|.
Yeast   187 FLNQMNVLSKILIPTVFDKNFLLLTAQIFFLVMRTWLSLFVAKLDGQIVKNIIAGRGRSFLWDLG 251

Human   136 QWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQ-TYYRV------SNMDGRLRNP 193
            .|.|||:||::.||||:.|:.:|:|:||..|..:.:.:|..:: |:|::      ||  ..::|.
Yeast   252 CWFLIAVPASYTNSAIKLLQRKLSLNFRVNLTRYIHDMYLDKRLTFYKLIFDAKASN--SVIKNI 314

Human   194 DQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVV--FLTAN 256
            |.|:|.||..|..:...:::|:.||::|:...|..|     ....||.   .:||:.|  |:|..
Yeast   315 DNSITNDVAKFCDATCSVFANIAKPVIDLIFFSVYL-----RDNLGTV---GVAGIFVNYFITGF 371

Human   257 VLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLIL 321
            :||.::|..|:|..|.:...|:....|..::.||||||||.|..||...::..|..|..::.|:.
Yeast   372 ILRKYTPPLGKLAGERSASDGDYYNYHLNMINNSEEIAFYQGTAVERTKVKELYDVLMEKMLLVD 436

Human   322 LERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFT 386
            ..:..|.|||.:::||.||..|.:..::||:.:|..:..::|       ||..:|        |.
Yeast   437 KVKFGYNMLEDYVLKYTWSGLGYVFASIPIVMSTLATGINSE-------EKNMKE--------FI 486

Human   387 IARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKR---PREL----EDAQ 444
            :.:.|:.:.|||..|:|.|.|::::|.|||.|:..:..|...|...:|..   |..|    |||.
Yeast   487 VNKRLMLSLADAGSRLMHSIKDISQLTGYTNRIFTLLSVLHRVHSLNFNYGAVPSILSIRTEDAS 551

Human   445 AGS--------------GTIGR--SGVRVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWS 493
            ..|              |||.|  :|:|:|....|         ||           |:|.|
Yeast   552 RNSNLLPTTDNSQDAIRGTIQRNFNGIRLENIDVI---------IP-----------SVRAS--- 593

Human   494 SWAPGGFPAERCWSARLPSQTVAAGHRTDSPFEGLSL--DYSFKTRGMWSPHPCRTARESSSQCA 556
                                            ||:.|  ..:|:......|   .|::.:|.|
Yeast   594 --------------------------------EGIKLINKLTFQIPLHIDP---ITSKSNSIQ-- 621

Human   557 SCWLPREAGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILG 621
                  :..:..|::       :|.:..||.              .|||.|||||||||:.||:.
Yeast   622 ------DLSKANDIK-------LPFLQGSGS--------------SLLILGPNGCGKSSIQRIIA 659

Human   622 GLWPTY--GGVLYKPPPQRMFYIPQRPYMS-VGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVV 683
            .:||.|  .|:|..|....:|:|||:||.| .|:||||:|||.|.::...:|:.:::|..||..|
Yeast   660 EIWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLRDQIIYPMSSDEFFDRGFRDKELVQILVEV 724

Human   684 HLHHILQREGG---WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQ 745
            .|.::|:|..|   .:|:.||||:||||||||:..||:.:|:|.|.:|||.|:|:|:|:|..:|.
Yeast   725 KLDYLLKRGVGLTYLDAIADWKDLLSGGEKQRVNFARIMFHKPLYVVLDEATNAISVDMEDYLFN 789

Human   746 AAKDAGIALLSITHRPSLWKYHTHLLQF--DGEGGWKFEKLDS-AARLSLTEEKQRLEQQL---A 804
            ..|......:||:.||:|.|||..||:.  :.:|.|:.:.:.: .|..|:..|.:.||::|   .
Yeast   790 LLKRYRFNFISISQRPTLIKYHEMLLEIGENRDGKWQLQAVGTDEAITSIDNEIEELERKLERVK 854

Human   805 GIPKMQRRLQELCQIL 820
            |....:.:|:|..:|:
Yeast   855 GWEDERTKLREKLEII 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		44/121 (36%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		4/12 (33%)
PXA1	NP_015178.1	3a01203	113..827	CDD:273360	236/751 (31%)