Protein Alignment ABCD1 and abcd1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: XP_005166771.1
• Gene: abcd1 / 566367
• ZFINID: ZDB-GENE-050517-27
• Length: 766
• Species: Danio rerio
• Alignment Length: 829
• Identity: 510/829 - (61%)
• Similarity: 604/829 - (72%)
• Gaps: 111/829 - (13%)

Human    15 LKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPA-------GEPTQEASGVAAAKAGMNRVFL 72
            |.:.||:|.:|.||..|:.|.....|......|...       |||..||:........:||.|.
Zfish    15 LVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFF 79

Human    73 QRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFGWQLLQW 137
            .||:.||::||||:.|:|.|||..||.||:||||||:|||.|||::.:.||:||||||..:|.:|
Zfish    80 DRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKW 144

Human   138 LLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVV 202
            ||||:||||||||||||||||.|:||:|||.|||.||||.|||||||||||||.|||||||||||
Zfish   145 LLIAIPATFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVV 209

Human   203 AFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGE 267
            .|||||||||||||||:|||.||.|||::.|.|:||.|.|||.|||:||.|||.|||||||:||:
Zfish   210 MFAASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGK 274

Human   268 LVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQ 332
            ||||||||||:|||||||::||||||||||||::|:..|||||..|:.||||||.:|||||||||
Zfish   275 LVAEEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQ 339

Human   333 FLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAAD 397
            |||||:||||||:|||||||||||||:.|:|.||:|||:.|||:||||||:|||.||:||.||||
Zfish   340 FLMKYLWSASGLVMVAVPIITATGYSKYDSEDVKQAALDMKEEDLVSERTQAFTTARSLLNAAAD 404

Human   398 AIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKR-PRELEDAQAGSGTIGRSGVRVEGPL 461
            |:||||.|||||||||||||||:|||:|||||:...::| ..|::..:.|:......|:||||||
Zfish   405 AVERIMVSYKEVTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPL 469

Human   462 KIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVAAGHRTDSPFE 526
            :||
Zfish   470 QIR-------------------------------------------------------------- 472

Human   527 GLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIPIVTPSGEVVVA 591
                                                  |||:||||||.|||:||:||:|:|||:
Zfish   473 --------------------------------------GQVIDVEQGIKCENLPIITPTGDVVVS 499

Human   592 SLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQ 656
            |||::|:||||||||||||||||||||||.||||.|.||||||.|..|||||||||||||:||||
Zfish   500 SLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVYSGVLYKPSPDHMFYIPQRPYMSVGTLRDQ 564

Human   657 VIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYH 721
            ||||.||::||.||.:::.||.||..|.|.:||:|||||:|:.|||||||||||||:||||||||
Zfish   565 VIYPHSVQEMQEKGITDRQLEEILQTVSLRYILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYH 629

Human   722 RPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDS 786
            :|:||||||||||||||||||||:|||||||:||||||||||||||:|||||||||||:|||||:
Zfish   630 KPQYALLDECTSAVSIDVEGKIFEAAKDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLDA 694

Human   787 AARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQ 835
            :.|:||.:||.|||.||:||||||:||.|||:||||   .:.:|.|..:
Zfish   695 STRISLQDEKIRLETQLSGIPKMQQRLTELCRILGE---DSSLPTPGDE 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		82/118 (69%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		8/16 (50%)
abcd1	XP_005166771.1	3a01203	1..689	CDD:273360	478/773 (62%)