Protein Alignment ABCD1 and Abcd1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_651906.1
• Gene: Abcd1 / 43772
• FlyBaseID: FBgn0039890
• Length: 730
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 342/737 - (46%)
• Similarity: 459/737 - (62%)
• Gaps: 119/737 - (16%)

Human    66 GMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAF 130
            |:|:.||:.|..|.:::.|:..|.|||||::|:..|:||||||:|||.|:|.|.:.|||||.:.|
  Fly   104 GLNKEFLKHLQMLAKIMIPQAFCYETGLLSVHTFCLISRTFLSIYVAALEGALVKFIVRKDIKQF 168

Human   131 GWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQ 195
            ...||:|..||:|||||||.||:||.:|:|:||:|||.|:|||||..|.||||||:|||:.|.|.
  Fly   169 ALVLLKWFGIAIPATFVNSMIRFLESKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADH 233

Human   196 SLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRA 260
            .||||:..||.|||||||:||||..|:.:....|:|:::...|......|::..|:.|||::||.
  Fly   234 RLTEDISVFANSVAHLYSSLTKPCFDLMLIGLALMRSSKKMKANIITGPALSIGVIALTAHILRI 298

Human   261 FSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERL 325
            .|||||:||:|||.|.|.||::|||::.|:|||||||||:||:..|:::|..|.:|:..|..::|
  Fly   299 VSPKFGQLVSEEANRYGYLRHIHSRIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKL 363

Human   326 WYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390
            |::|||||.||||||.:|::||::||:|.   |:.....|...|:   .|..|||||:..|.|||
  Fly   364 WFIMLEQFFMKYVWSGTGMIMVSLPILTG---SDVGLGTVPNTAI---SESRVSERTQYLTTARN 422

Human   391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGV 455
            ||.:|||||||:||||||:..|||||.||..|..|||:.....:.:...:|..|:
  Fly   423 LLISAADAIERLMSSYKEIVSLAGYTFRVAGMMDVFEETALGVYCKTSVMESNQS---------- 477

Human   456 RVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVAAGHR 520
              .|.::.|...      |:..||
  Fly   478 --NGIIEFRNGK------PIAKGR----------------------------------------- 493

Human   521 TDSPFEGLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIPIVTPS 585
                     :.||...:.|                                 .|....:|:|||:
  Fly   494 ---------IIYSDDPKNM---------------------------------SISLRAVPVVTPN 516

Human   586 GEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQR----MFYIPQRP 646
            .::||..|.:.:|.|:|||||||||||||||||||.||||.|.|.|:.|.|.:    ||||||||
  Fly   517 CDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPCMFYIPQRP 581

Human   647 YMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQ 711
            |||:|||.||:||||:.|||:||..:|.:|.:||.:|.|.||.||: .::.:.||||:|||||||
  Fly   582 YMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKDILSGGEKQ 645

Human   712 RIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGE 776
            |:.:||:|||||:||||||||||||||||..|::.||..||.||:|||||:|||||||:|:|||.
  Fly   646 RMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHTHILEFDGL 710

Human   777 GGWKFEKLDSAARLSLTEEKQR 798
            |.|:|.|::|       :|:|:
  Fly   711 GNWQFRKMNS-------DEEQK 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		67/118 (57%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		5/16 (31%)
Abcd1	NP_651906.1	3a01203	75..715	CDD:273360	337/718 (47%)