Protein Alignment ABCD1 and Abcd1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_001102291.1
• Gene: Abcd1 / 363516
• RGDID: 1562128
• Length: 737
• Species: Rattus norvegicus
• Alignment Length: 839
• Identity: 672/839 - (80%)
• Similarity: 692/839 - (82%)
• Gaps: 106/839 - (12%)

Human     1 MPVLSRP-RPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGVAAAK 64
            |||||.| ||.|..|||||||:|||.|||.||:||||||||.||||.|.||||.||||||...||
  Rat     1 MPVLSTPSRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGESTQEASGATTAK 65

Human    65 AGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRA 129
            ||||||||||||.|||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 AGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRA 130

Human   130 FGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPD 194
            |.|||||||||||||||:||||||||||||||||||||||||.||||||||||||||||||||||
  Rat   131 FSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPD 195

Human   195 QSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLR 259
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 QSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLR 260

Human   260 AFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLER 324
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
  Rat   261 AFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLER 325

Human   325 LWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIAR 389
            |||||||||||||||||||||||||||||||||:|||:||:||||||.|||||||||||||||||
  Rat   326 LWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIAR 390

Human   390 NLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSG 454
            |||||||||.||||||||||||||||||||:||||||||||.|.|||..:||:||||.|::..||
  Rat   391 NLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVQHCRFKRTGDLEEAQAGPGSMVHSG 455

Human   455 VRVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVAAGH 519
            |.:||||||:
  Rat   456 VHIEGPLKIQ------------------------------------------------------- 465

Human   520 RTDSPFEGLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIPIVTP 584
                                                         |||||||||||||||||:||
  Rat   466 ---------------------------------------------GQVVDVEQGIICENIPIITP 485

Human   585 SGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMS 649
            :||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
  Rat   486 TGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMS 550

Human   650 VGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIG 714
            |||||||||||||.|||:|||.|||.|||||.:|||.|||||||||||:||||||||||||||||
  Rat   551 VGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIG 615

Human   715 MARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGW 779
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat   616 MARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGISLLSITHRPSLWKYHTHLLQFDGEGGW 680

Human   780 KFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQGPG 838
            |||||||||||||||||||||||||||||||.|||||.||||||.||.     .|..||
  Rat   681 KFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPV-----QPLVPG 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		113/118 (96%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		15/16 (94%)
Abcd1	NP_001102291.1	3a01203	1..682	CDD:273360	625/780 (80%)
		Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P33897	68..187		113/118 (96%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250|UniProtKB:P33897	68..85		15/16 (94%)
		Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P33897	659..737		69/81 (85%)