Protein Alignment ABCD1 and pmp-4

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_001293680.1
• Gene: pmp-4 / 24104835
• WormBaseID: WBGene00004061
• Length: 734
• Species: Caenorhabditis elegans
• Alignment Length: 764
• Identity: 379/764 - (49%)
• Similarity: 502/764 - (65%)
• Gaps: 117/764 - (15%)

Human    64 KAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPR 128
            |...:..||::|..||:::.|.|..:|.|::.:||..|:.||||:::||:|:|.:.:.||.|:..
 Worm    66 KKAFDPQFLKQLKELLKIMIPGVFSKEAGIIGMHSIILICRTFLTIFVAQLEGSMVQAIVEKNVL 130

Human   129 AFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNP 193
            .|...|::|:|:|||||||||.||:.|..|.|:||:||..|||:.|||.||||.|||:|.||:|.
 Worm   131 QFVLHLVKWILVALPATFVNSMIRFFESYLGLAFRTRLTKHAYKQYFSDQTYYAVSNLDTRLQNA 195

Human   194 DQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAG--TAWPSAIAGLVVFLTAN 256
            ||.||||:..|:.|||||||:||||:||||:.::||::.|..||.|  |..||.:|.:.|.|||.
 Worm   196 DQCLTEDITMFSQSVAHLYSHLTKPVLDVALITFTLIKLAIQRGTGRSTFLPSCMAIMAVSLTAK 260

Human   257 VLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLIL 321
            :|||.||:||.:|||||||||.|||:|||::.|||||||||||:.|...|..::..|..|:.||.
 Worm   261 ILRAVSPRFGHMVAEEARRKGHLRYLHSRIITNSEEIAFYGGHQAEYKQLDGAFNSLYQQMMLIF 325

Human   322 LERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFT 386
            .:|:.|:|:||||||||||.:|::|:|:||: ||.|::.:    |...||...:..|||||..:.
 Worm   326 KKRIPYIMIEQFLMKYVWSGTGMVMIALPIL-ATEYADDE----KSTKLEDLPDRGVSERTRGYA 385

Human   387 IARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIG 451
            .|:.||..:|||:||:|:||||||||||||.|||||||||:|.::..::|    :...||:
 Worm   386 TAKTLLFNSADAVERLMTSYKEVTELAGYTGRVHEMFQVFDDAKKGIYQR----QTVSAGA---- 442

Human   452 RSGVRVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVA 516
                                       .:|.|
 Worm   443 ---------------------------EQGQR--------------------------------- 447

Human   517 AGHRTD-SPFEGLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIP 580
             |.|.| |..||:..|                              .||.:       ||..::|
 Worm   448 -GERFDTSKIEGIITD------------------------------SEADE-------IILNSVP 474

Human   581 IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQR 645
            ||||:|:|||.::.:.:..|||:||||||||||||||||||||||.|.|.|.||...||:|||||
 Worm   475 IVTPNGDVVVKNMTLTISPGMHVLITGPNGCGKSSLFRILGGLWPVYRGHLEKPTSDRMYYIPQR 539

Human   646 PYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEK 710
            |||::|:|||||||||:...|:|:|.::|||..:|.:|||.||::|||||:|..||.||||||||
 Worm   540 PYMTLGTLRDQVIYPDTTIQMRRQGITDQDLMTMLRIVHLEHIVEREGGWDAQNDWMDVLSGGEK 604

Human   711 QRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDG 775
            ||:||||:|||||||||||||||||||||||.|:||.||:||.||::||||||||:||||||:||
 Worm   605 QRMGMARVFYHRPKYALLDECTSAVSIDVEGSIYQAIKDSGITLLTVTHRPSLWKFHTHLLQYDG 669

Human   776 EGGWKFEKLDS---AARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILG 821
            |||:|...|:.   ..|:|.:||||:||:|||.:|:.:.||:|:||:||
 Worm   670 EGGYKVSSLNEKTIGERMSYSEEKQQLEKQLAEVPRWKERLEEVCQLLG 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		57/118 (48%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		5/16 (31%)
pmp-4	NP_001293680.1	3a01203	37..674	CDD:273360	358/718 (50%)