Protein Alignment ABCD1 and Abcd1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: NP_031461.1
• Gene: Abcd1 / 11666
• MGIID: 1349215
• Length: 736
• Species: Mus musculus
• Alignment Length: 838
• Identity: 676/838 - (80%)
• Similarity: 694/838 - (82%)
• Gaps: 105/838 - (12%)

Human     1 MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGVAAAKA 65
            |||||.|||.|..|||||||:|||.|||.||:||||||||.||||.|.|||||||||||..|.||
Mouse     1 MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQEASGATATKA 65

Human    66 GMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAF 130
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 GMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAF 130

Human   131 GWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQ 195
            .|||||||||||||||:||||||||||||||||||||||||.|||||||||||||||||||||||
Mouse   131 SWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQ 195

Human   196 SLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 SLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRA 260

Human   261 FSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERL 325
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
Mouse   261 FSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERL 325

Human   326 WYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390
            ||||||||||||||||||||||||||||||||:|||:||:||||||.||||||||||||||||||
Mouse   326 WYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARN 390

Human   391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGV 455
            ||||||||.||||||||||||||||||||:|||||||||:.|.|||..:||:||||.|.:.:|||
Mouse   391 LLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVMVQSGV 455

Human   456 RVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVAAGHR 520
            .|||||||:
Mouse   456 HVEGPLKIQ-------------------------------------------------------- 464

Human   521 TDSPFEGLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIPIVTPS 585
                                                        |||||||||||||||||:||:
Mouse   465 --------------------------------------------GQVVDVEQGIICENIPIITPT 485

Human   586 GEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSV 650
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse   486 GEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSV 550

Human   651 GSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGM 715
            ||||||||||||.|||:|||.|||.|||||.:|||.|||||||||||:|||||||||||||||||
Mouse   551 GSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGM 615

Human   716 ARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWK 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   616 ARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWK 680

Human   781 FEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQGPG 838
            ||||||||||||||||||||||||||||||.|||||.||||||.||.     .|..||
Mouse   681 FEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPV-----QPLVPG 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		114/118 (97%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		15/16 (94%)
Abcd1	NP_031461.1	3a01203	1..681	CDD:273360	629/779 (81%)
		Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P33897	67..186		114/118 (97%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250|UniProtKB:P33897	67..84		15/16 (94%)
		Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P33897	658..736		69/81 (85%)