Protein Alignment ABCD1 and abcd1

DIOPT Version :10

• Sequence 1: NP_001427676.1
• Gene: ABCD1 / 215
• HGNCID: 61
• Length: 845
• Species: Homo sapiens
• Sequence 2: XP_002935559.1
• Gene: abcd1 / 100493545
• XenbaseID: XB-GENE-953036
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 822
• Identity: 553/822 - (67%)
• Similarity: 642/822 - (78%)
• Gaps: 106/822 - (12%)

Human     7 PRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQ-CL-----APARGLQAPAGEPTQEASGVAAAKA 65
            |.|...:.:.:..|.||||||||.::|||:|. ||     ..|.||.......:..:|..:..:.
 Frog     6 PSPVTRSAVLKRVVALALAAYGARRIYPLLRHLCLQLQKHPKANGLPGSTEASSSSSSLNSYERT 70

Human    66 GMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAF 130
            .:||.|.:||:.|||||||::.|:|.|||.||||||:||||||||||:|||||.|.||:|.|.:|
 Frog    71 SVNRAFFRRLVRLLRLLFPKLACKEFGLLILHSAALISRTFLSVYVAQLDGRLTRAIVKKRPASF 135

Human   131 GWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQ 195
            .||||:||||||||||:|||||||||||:|:||:|||||||:|||.|||||||||||||||||||
 Frog   136 VWQLLKWLLIALPATFINSAIRYLEGQLSLAFRTRLVAHAYQLYFGQQTYYRVSNMDGRLRNPDQ 200

Human   196 SLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRA 260
            ||||||||||.||||||||||||:|||.||:||||..|:|:||.|||||.||||||.:||.|||:
 Frog   201 SLTEDVVAFANSVAHLYSNLTKPVLDVVVTTYTLLSTAKSKGANTAWPSTIAGLVVIITAKVLRS 265

Human   261 FSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERL 325
            .|||||:||||||||||||||||||||||||||||||||:||::||::.|:||:||||:||||||
 Frog   266 CSPKFGKLVAEEARRKGELRYMHSRVVANSEEIAFYGGHKVEMSLLRKCYEDLSSQINIILLERL 330

Human   326 WYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390
            |||||||||||||||||||:||||||||||||::||:|.|||||:|.|||||||||.||||.|||
 Frog   331 WYVMLEQFLMKYVWSASGLVMVAVPIITATGYADSDSEEVKKAAMEMKEEELVSERAEAFTTARN 395

Human   391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGV 455
            ||||:||||||:||||||||||||||||||:||:||||||:..:|||.|||:|::.:..:.:.|:
 Frog   396 LLTASADAIERVMSSYKEVTELAGYTARVHDMFEVFEDVQKGIYKRPGELEEAESKNRGVIQHGI 460

Human   456 RVEGPLKIRGTSMCFWPIPVHPGREGCRAGSLRTSAWSSWAPGGFPAERCWSARLPSQTVAAGHR 520
            |:||||:|:
 Frog   461 RMEGPLEIK-------------------------------------------------------- 469

Human   521 TDSPFEGLSLDYSFKTRGMWSPHPCRTARESSSQCASCWLPREAGQVVDVEQGIICENIPIVTPS 585
                                                        |:|||||.||||||||||||:
 Frog   470 --------------------------------------------GKVVDVENGIICENIPIVTPT 490

Human   586 GEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSV 650
            |:|||..|||:|||||||||||||||||||||||||||||.|.|||||||||.||||||||||||
 Frog   491 GDVVVERLNIQVEEGMHLLITGPNGCGKSSLFRILGGLWPAYKGVLYKPPPQHMFYIPQRPYMSV 555

Human   651 GSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGM 715
            |:|||||||||:.|||:||.:::::|||||::|:|.:::||||||:::.|||||||||||||:||
 Frog   556 GTLRDQVIYPDTAEDMRRKSFTDKNLEAILNIVNLIYLVQREGGWDSVSDWKDVLSGGEKQRVGM 620

Human   716 ARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWK 780
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   621 ARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWK 685

Human   781 FEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGE 822
            |||||:|||||||||||||||||||:||||:||.||||:|||
 Frog   686 FEKLDTAARLSLTEEKQRLEQQLAGVPKMQQRLGELCQLLGE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD1	NP_001427676.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	67..186		90/118 (76%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000269|PubMed:15781447	67..84		10/16 (63%)
abcd1	XP_002935559.1	3a01203	11..686	CDD:273360	513/774 (66%)