DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EZH2 and SET2

DIOPT Version :9

Sequence 1:	XP_011514185.1	Gene:	EZH2 / 2146	HGNCID:	3527	Length:	759	Species:	Homo sapiens
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	220	Identity:	74/220 - (33%)
Similarity:	99/220 - (45%)	Gaps:	58/220 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   547 CPCVIAQNFCEKF-------CQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAA 604
            |.|.      |:|       |...|:|.||                  |.:.||..|||.:||
Yeast    68 CDCY------EEFSDGVNHACDEDSDCINR------------------LTLIECVNDLCSSCG-- 106

Human   605 DHWDSKNVSCKNCSIQRGSKKHLLLAPSDV-----AGWGIFIKDPVQKNEFISEYCGEIISQDEA 664
                      .:|..||..||.  .||..:     .|:|:..:..::.|:||.||.||:|.:.|.
Yeast   107 ----------NDCQNQRFQKKQ--YAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEF 159

Human   665 DRRGKVYD-KYMCSFLFNL--NNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAK 726
            ..|...|| ::...|.|.:  |.:| :|||.||:..||.|||.:||.|....:|....|:||||:
Yeast   160 RDRLIDYDQRHFKHFYFMMLQNGEF-IDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQ 223

Human   727 RAIQTGEELFFDY---RYSQADALK 748
            |.|..|||:.|||   ||. |.|.|
Yeast   224 RKILKGEEITFDYNVDRYG-AQAQK 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EZH2	XP_011514185.1	EZH2_WD-Binding	47..75	CDD:314486
EZH2	XP_011514185.1	SET	625..746	CDD:214614	51/131 (39%)
SET2	NP_012367.2	AWS	64..119	CDD:197795	22/88 (25%)
		SET_SETD2	119..260	CDD:380949	52/131 (40%)
		SET	215..695	CDD:225491	18/34 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2678
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860