DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EZH2 and mes-2

DIOPT Version :9

Sequence 1:	XP_011514185.1	Gene:	EZH2 / 2146	HGNCID:	3527	Length:	759	Species:	Homo sapiens
Sequence 2:	NP_496992.3	Gene:	mes-2 / 175096	WormBaseID:	WBGene00003220	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	216/898 - (24%)
Similarity:	321/898 - (35%)	Gaps:	301/898 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    12 TGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNR-------QKILERTEILN---- 65
            :||..::|..|.....||:  :.:.|.||.:   ::.:|||.:       |.|.|...:|.
Worm    12 SGKTKKRGKKCETSMGKSK--KSKNLPRFVK---IQPIFSSEKIKETVCEQGIEECKRMLKGHFN 71

Human    66 ------------------QEW----------KQRRIQPVHILTSVSSLR-----GTRECSVTSDL 97
                              ::|          .:||:|     .::...|     ..:.|....:.
Worm    72 AIKDDYDIRVKDELDTDIKDWLKDASSSVNEYRRRLQ-----ENLGEGRTIAKFSFKNCEKYEEN 131

Human    98 DFP------TQVIP--------LKTLNAVAS-------VPIMYSWSPLQQNFMVEDETVLHNIPY 141
            |:.      |.:.|        :|...|..|       .|.|..|.|::|:....|:..|.::||
Worm   132 DYKVSDSTVTWIKPDRTEEGDLMKKFRAPCSRIEVGDISPPMIYWVPIEQSVATPDQLRLTHMPY 196

Human   142 MGDEVLDQDGTFIEELIKNYDGKVHG-DRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEERE 205
            .||.:  .||...|.||..:...:|| .....::||.|..:|..|.
Worm   197 FGDGI--DDGNIYEHLIDMFPDGIHGFSDNWSYVNDWILYKLCRAA------------------- 240

Human   206 EKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQL-----PGALP 265
                 |:|::..          .|..:..:..::|:|.:..|....:..|.|...     |.:|.
Worm   241 -----LKDYQGS----------PDVFYYTLYRLWPNKSSQREFSSAFPVLCENFAEKGFDPSSLE 290

Human   266 P-------ECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH--------RKCNYSFH-- 313
            |       |...|:..|.                 |..|..|.|.:|        ...|..|:
Worm   291 PWKKTKIAEGAQNLRNPT-----------------CYACLAYTCAIHGFKAEIPIEFPNGEFYNA 338

Human   314 --ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSS 376
              ..||     |.|.  |.|.|...|::.:. .||.:..|..
Worm   339 MLPLPN-----NPEN--DGKMCSGNCWKSVT-MKEVSEVLVP----------------------- 372

Human   377 RPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIK---MKPNIE 438
                                          |.||..:|:               :|   ||..|.
Worm   373 ------------------------------DSEEILQKE---------------VKIYFMKSRIA 392

Human   439 --PPENVEWSGAEASMFRVLIGTYYDNFCAIARLI--------GTKTCRQVYEFRVKESSIIAP- 492
              |.|:      .|.:..:.:...|..||...:..        ..::||..|...:..:..::.
Worm   393 KMPIED------GALIVNIYVFNTYIPFCEFVKKYVDEDDEESKIRSCRDAYHLMMSMAENVSAR 451

Human   493 -----APAEDVDTPPR------------KKKRKHRLWAAH-CRKIQLKKDG-------------- 525
                 .|:..:....|            |.|||.|    | ..:||..:||
Worm   452 RLKMGQPSNRLSIKDRVNNFRRNQLSQEKAKRKLR----HDSLRIQALRDGLDAEKLIREDDMRD 512

Human   526 --------SSNHVYNYQPCDHPRQPCDSSCP-CVIAQN-FCEKFCQCSSECQNRFPGCRCKA-QC 579
                    ....|.....|.| ..||:::.. |...:| .|...|:|...|..|||||.|.| ||
Worm   513 SQRNSEKVRMTAVTPITACRH-AGPCNATAENCACRENGVCSYMCKCDINCSQRFPGCNCAAGQC 576

Human   580 NTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDP 644
            .||.|.||.|..||:|..|..| ..|..||..:.|:|..:.|..:|.....||.:||.|:|:.:|
Worm   577 YTKACQCYRANWECNPMTCNMC-KCDAIDSNIIKCRNFGMTRMIQKRTYCGPSKIAGNGLFLLEP 640

Human   645 VQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANH-SVNPNC 708
            .:|:|||:||.||.||.|||:|||.:||:|.||::||:.....:|:.:.||..||||| |.||.|
Worm   641 AEKDEFITEYTGERISDDEAERRGAIYDRYQCSYIFNIETGGAIDSYKIGNLARFANHDSKNPTC 705

Human   709 YAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYS--QADALKYVGIEREMEIP 759
            ||:.|:|.|:||||.:|||.::..|||.|||.||  ...|.:.|..:...|.|
Worm   706 YARTMVVAGEHRIGFYAKRRLEISEELTFDYSYSGEHQIAFRMVQTKERSEKP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EZH2	XP_011514185.1	EZH2_WD-Binding	47..75	CDD:314486	10/66 (15%)
EZH2	XP_011514185.1	SET	625..746	CDD:214614	63/123 (51%)
mes-2	NP_496992.3	Septum_form	<210..265	CDD:290557	14/88 (16%)
mes-2	NP_496992.3	SET	621..742	CDD:214614	63/120 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3631
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I2337
Isobase	1	0.950	-	0	Normalized mean entropy	S2678
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		otm16259
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	LDO	PTHR45747
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870