DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tcp1 and CCT1

DIOPT Version :9

Sequence 1:	NP_038714.2	Gene:	Tcp1 / 21454	MGIID:	98535	Length:	556	Species:	Mus musculus
Sequence 2:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	403/555 - (72%)
Similarity:	473/555 - (85%)	Gaps:	2/555 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MEGPLSVFGDRSTGEAVRSQNVMAAASIANIVKSSFGPVGLDKMLVDDIGDVTITNDGATILKLL 65
            :..|||:.|.|.:|.:||:||||||.||:||||||.|||||||||||||||||:||||||||:||
  Fly     4 LASPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLL 68

Mouse    66 EVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVR 130
            ||||||||||.|||.|||:|||||||||||:||||||||||||||||||||:|||||:|||||.:
  Fly    69 EVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACK 133

Mouse   131 YINENLIINTDELGRDCLINAAKTSMSSKIIGINGDYFANMVVDAVLAVKYTDARGQPRYPVNSV 195
            ||:|:|....||||||.|||.|||||||||||.:.::|:.|||||..:||.||.|||..|.:.::
  Fly   134 YISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAI 198

Mouse   196 NILKAHGRSQIESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKL 260
            |:|||||:|..||:||.||||||.:.||.|||:|||||||||||||||||||:||||:|.||:||
  Fly   199 NVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKL 263

Mouse   261 DQIRQRESDITKERIQKILATGANVILTTGGIDDMYLKYFVEAGAMAVRRVLKRDLKHVAKASGA 325
            :.||.||.|||||||..||.||.||:|.:||:||:.:||||||||||||||.|.|||.:|||:||
  Fly   264 EAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGA 328

Mouse   326 SILSTLANLEGEETFEVTMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMER 390
            :.:::|.|::|||:|:.:|:|:|.||.|||||||||||||.||||.:|||||||.|||.||||||
  Fly   329 AFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMER 393

Mouse   391 SLHDALCVVKRVLELKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVN 455
            |:||||||||||||.|.||.|||.|||||||||||:|||:.|||||||||||:||||||.||:||
  Fly   394 SVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVN 458

Mouse   456 AAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEA 520
            ||:|:||||||||::||.:|..|||.:|||.||||:.|..||||:|||.||.:.|:|||||||||
  Fly   459 AAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEA 523

Mouse   521 AITILRIDDLIKLHPESKDDKHGSYENAVHSGALD 555
            |||||||||:|||:||.|..|  ||.:|..:|.||
  Fly   524 AITILRIDDMIKLNPEDKSGK--SYADACAAGELD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tcp1	NP_038714.2	chap_CCT_alpha	5..540	CDD:274081	395/534 (74%)
Tcp1	NP_038714.2	TCP1_alpha	9..535	CDD:239451	390/525 (74%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	390/525 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831634
Domainoid	1	1.000	749	1.000	Domainoid score	I91
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5656
Inparanoid	1	1.050	793	1.000	Inparanoid score	I508
Isobase	1	0.950	-	0	Normalized mean entropy	S29
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	1	1.000	-	-		FOG0005251
OrthoInspector	1	1.000	-	-		oto94712
orthoMCL	1	0.900	-	-		OOG6_101890
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1484
SonicParanoid	1	1.000	-	-		X3773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750