DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EZH1 and SET2

DIOPT Version :9

Sequence 1:	NP_001308008.1	Gene:	EZH1 / 2145	HGNCID:	3526	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_012367.2	Gene:	SET2 / 853271	SGDID:	S000003704	Length:	733	Species:	Saccharomyces cerevisiae

Alignment Length:	295	Identity:	82/295 - (27%)
Similarity:	130/295 - (44%)	Gaps:	77/295 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   491 ELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDS-------TCPCIMTQN 548
            |::|.:.:..:..||:.   ::..|.:: :.|:..|...|.:.::...:       .|.|.
Yeast    15 EILNNNAEGHKPQRLFD---QEPDLTEE-ALTKFENLDDCIYANKRIGTFKNNDFMECDCY---- 71

Human   549 FCEKF-------CQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV 606
              |:|       |..:.||.||                  |.:.||..|||.:||
Yeast    72 --EEFSDGVNHACDEDSDCINR------------------LTLIECVNDLCSSCG---------- 106

Human   607 SCKNCSIQRGLKKHLLLAPSDV-----AGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD 666
              .:|..||..||.  .||..:     .|:|...::.::.|:||.||.||:|.:.|...|...||
Yeast   107 --NDCQNQRFQKKQ--YAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYD 167

Human   667 -KYMSSFLFNL--NNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEE 728
             ::...|.|.:  |.:| :|||.||:..||.|||.:||.|....:|....|:||||:|.|..|||
Yeast   168 QRHFKHFYFMMLQNGEF-IDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEE 231

Human   729 LFFDY---RY---------SQADALKYVGIERETD 751
            :.|||   ||         .:.:.:.::|.:.:||
Yeast   232 ITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTD 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EZH1	NP_001308008.1	EZH2_WD-Binding	45..73	CDD:288468
		SANT	439..480	CDD:238096
		SANT	439..480	CDD:197842
		SET	<469..733	CDD:225491	75/263 (29%)
		SET	619..740	CDD:214614	50/140 (36%)
SET2	NP_012367.2	AWS	64..119	CDD:197795	22/92 (24%)
		SET_SETD2	119..260	CDD:380949	49/141 (35%)
		SET	215..695	CDD:225491	18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910