Protein Alignment EZH1 and SET2

DIOPT Version :10

• Sequence 1: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 295
• Identity: 82/295 - (27%)
• Similarity: 130/295 - (44%)
• Gaps: 77/295 - (26%)

Human   491 ELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDS-------TCPCIMTQN 548
            |::|.:.:..:..||:.   ::..|.:: :.|:..|...|.:.::...:       .|.|.
Yeast    15 EILNNNAEGHKPQRLFD---QEPDLTEE-ALTKFENLDDCIYANKRIGTFKNNDFMECDCY---- 71

Human   549 FCEKF-------CQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV 606
              |:|       |..:.||.||                  |.:.||..|||.:||
Yeast    72 --EEFSDGVNHACDEDSDCINR------------------LTLIECVNDLCSSCG---------- 106

Human   607 SCKNCSIQRGLKKHLLLAPSDV-----AGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD 666
              .:|..||..||.  .||..:     .|:|...::.::.|:||.||.||:|.:.|...|...||
Yeast   107 --NDCQNQRFQKKQ--YAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYD 167

Human   667 -KYMSSFLFNL--NNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEE 728
             ::...|.|.:  |.:| :|||.||:..||.|||.:||.|....:|....|:||||:|.|..|||
Yeast   168 QRHFKHFYFMMLQNGEF-IDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEE 231

Human   729 LFFDY---RY---------SQADALKYVGIERETD 751
            :.|||   ||         .:.:.:.::|.:.:||
Yeast   232 ITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTD 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308
		PRC2_HTH_1	165..268	CDD:436286
		SANT	439..480	CDD:238096
		preSET_CXC	566..597	CDD:408079	7/30 (23%)
		SET_EZH1	614..749	CDD:380994	54/154 (35%)
SET2	NP_012367.2	AWS	64..119	CDD:197795	22/92 (24%)
		SET_SETD2	119..260	CDD:380949	49/141 (35%)
		WW_1	479..505	CDD:375933
		TolA	545..>626	CDD:442298
		SRI	627..703	CDD:462404