Protein Alignment EZH1 and ezh1

DIOPT Version :10

• Sequence 1: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Sequence 2: NP_001035072.2
• Gene: ezh1 / 664754
• ZFINID: ZDB-GENE-050114-1
• Length: 756
• Species: Danio rerio
• Alignment Length: 786
• Identity: 508/786 - (64%)
• Similarity: 595/786 - (75%)
• Gaps: 63/786 - (8%)

Human     1 MEDYSKMEIPNPPTSK---CITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQIL 62
            ||:.|.   |.|.|.|   .:..||::|||||||||||||.:.....|||:.:|..|::..|::|
Zfish     1 MEEVSG---PRPCTVKPRQDLLEWKKRVKSEYMRLRQLKRFRKAEQVKALFQSNRRKIEVGTELL 62

Human    63 NEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNF 127
            ||||.|||:|.:.........|..|.|.:|..||.|.:|.:.||.|.|||.:|.|||||||||||
Zfish    63 NEEWSKLRIQSIPLSTSSGSLPSKKLCMVEFGFPSFPNQAVAMRPLTTVAGIPFMYSWSPLQQNF 127

Human   128 MVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEE----MIPGSVLISDAVFLELVDA 188
            ||||||.|.|||||||||.|:||.|:||||:|||| |||:..    :|.|. .|:|.:|.|||:|
Zfish   128 MVEDETFLHNIPYMGDEVLEQDEAFLEELIDNYDG-VHGDRVSCTFLIEGG-FINDEIFKELVEA 190

Human   189 LNQYSD----EEEEGHNDTSDGKQDDSKE------DLPVTR-----KRK-RHAIEGNKKSSKKQF 237
            |:||||    |||:...|.::.||::.||      :.|...     ||| |:..||.:.|:.|:.
Zfish   191 LSQYSDPEEEEEEKEPTDAAENKQEEEKEMQKSAAEAPEESKTAFFKRKWRNTAEGRELSANKKI 255

Human   238 PNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT 302
            |:|.||:|||||||..|...::|::|.:|.|.|:...|||.||||:|||.|||||||||||||||
Zfish   256 PHDKIFTAIASMFPYKGTMQELKDKYLDLLEPSNHVKLPPLCTPNMDGPFAKSVQREQSLHSFHT 320

Human   303 LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYA---MLHNPRSKCS 364
            |||||||||||||||||::|||||||:|||.:|.||||.|||||.:||||:|   |:.:.|:
Zfish   321 LFCRRCFKYDCFLHPFHSSPNVYKRKSKEIHMETEPCGLDCFLLQKGAKEFADQNMMRSQRT--- 382

Human   365 GRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTK-------QKAS 422
             |||||....|:||.:....:..:.|||.||.:|     :||||.||||.:|.|       .|.|
Zfish   383 -RRRRRQPRPSSSCGHTPPDSSEKGKEGGSDHET-----TSSSEGNSRCPSPIKMKPGEEESKES 441

Human   423 PAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKL 487
            .:|||            |:|||||||||.||||:|||||||||:|||||::|::|||||.||.::
Zfish   442 KSPPQ------------WSGAEESLFRVLHGTYYNNFCSIARLIGTKTCREVYEFAVKEVLIDRM 494

Human   488 PTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEK 552
            |.::.....|||||||||||    ||||||||||.|||||||||||:.||||:|||::|||||||
Zfish   495 PLEDSGISPQKKKRKHRLWA----KIQLKKDNSSNQVYNYQPCDHPEHPCDSSCPCVITQNFCEK 555

Human   553 FCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL 617
            ||||:.:|||||||||||||||||||||||||||||||||:||||::|||.|.||||||||||||
Zfish   556 FCQCDRECQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKQVSCKNCSIQRGL 620

Human   618 KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVV 682
            ||||||||||||||||||||.||||||||||||||||||||||||::||||||||||||||||||
Zfish   621 KKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVV 685

Human   683 DATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIE 747
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
Zfish   686 DATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKYVGIE 750

Human   748 RETDVL 753
            ||.:::
Zfish   751 REIEIV 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308	15/28 (54%)
		PRC2_HTH_1	165..268	CDD:436286	48/122 (39%)
		SANT	439..480	CDD:238096	31/40 (78%)
		preSET_CXC	566..597	CDD:408079	29/30 (97%)
		SET_EZH1	614..749	CDD:380994	130/134 (97%)
ezh1	NP_001035072.2	EZH2_WD-Binding	45..74	CDD:463308	15/28 (54%)
		PRC2_HTH_1	164..286	CDD:436286	48/122 (39%)
		SANT	447..489	CDD:238096	33/41 (80%)
		preSET_CXC	569..600	CDD:408079	29/30 (97%)
		SET_EZH1	617..752	CDD:380994	130/134 (97%)