DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EZH1 and ezh1

DIOPT Version :9

Sequence 1:	NP_001308008.1	Gene:	EZH1 / 2145	HGNCID:	3526	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_001035072.2	Gene:	ezh1 / 664754	ZFINID:	ZDB-GENE-050114-1	Length:	756	Species:	Danio rerio

Alignment Length:	786	Identity:	508/786 - (64%)
Similarity:	595/786 - (75%)	Gaps:	63/786 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEDYSKMEIPNPPTSK---CITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQIL 62
            ||:.|.   |.|.|.|   .:..||::|||||||||||||.:.....|||:.:|..|::..|::|
Zfish     1 MEEVSG---PRPCTVKPRQDLLEWKKRVKSEYMRLRQLKRFRKAEQVKALFQSNRRKIEVGTELL 62

Human    63 NEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNF 127
            ||||.|||:|.:.........|..|.|.:|..||.|.:|.:.||.|.|||.:|.|||||||||||
Zfish    63 NEEWSKLRIQSIPLSTSSGSLPSKKLCMVEFGFPSFPNQAVAMRPLTTVAGIPFMYSWSPLQQNF 127

Human   128 MVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEE----MIPGSVLISDAVFLELVDA 188
            ||||||.|.|||||||||.|:||.|:||||:|||| |||:..    :|.|. .|:|.:|.|||:|
Zfish   128 MVEDETFLHNIPYMGDEVLEQDEAFLEELIDNYDG-VHGDRVSCTFLIEGG-FINDEIFKELVEA 190

Human   189 LNQYSD----EEEEGHNDTSDGKQDDSKE------DLPVTR-----KRK-RHAIEGNKKSSKKQF 237
            |:||||    |||:...|.::.||::.||      :.|...     ||| |:..||.:.|:.|:.
Zfish   191 LSQYSDPEEEEEEKEPTDAAENKQEEEKEMQKSAAEAPEESKTAFFKRKWRNTAEGRELSANKKI 255

Human   238 PNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT 302
            |:|.||:|||||||..|...::|::|.:|.|.|:...|||.||||:|||.|||||||||||||||
Zfish   256 PHDKIFTAIASMFPYKGTMQELKDKYLDLLEPSNHVKLPPLCTPNMDGPFAKSVQREQSLHSFHT 320

Human   303 LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYA---MLHNPRSKCS 364
            |||||||||||||||||::|||||||:|||.:|.||||.|||||.:||||:|   |:.:.|:
Zfish   321 LFCRRCFKYDCFLHPFHSSPNVYKRKSKEIHMETEPCGLDCFLLQKGAKEFADQNMMRSQRT--- 382

Human   365 GRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTK-------QKAS 422
             |||||....|:||.:....:..:.|||.||.:|     :||||.||||.:|.|       .|.|
Zfish   383 -RRRRRQPRPSSSCGHTPPDSSEKGKEGGSDHET-----TSSSEGNSRCPSPIKMKPGEEESKES 441

Human   423 PAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKL 487
            .:|||            |:|||||||||.||||:|||||||||:|||||::|::|||||.||.::
Zfish   442 KSPPQ------------WSGAEESLFRVLHGTYYNNFCSIARLIGTKTCREVYEFAVKEVLIDRM 494

Human   488 PTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEK 552
            |.::.....|||||||||||    ||||||||||.|||||||||||:.||||:|||::|||||||
Zfish   495 PLEDSGISPQKKKRKHRLWA----KIQLKKDNSSNQVYNYQPCDHPEHPCDSSCPCVITQNFCEK 555

Human   553 FCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGL 617
            ||||:.:|||||||||||||||||||||||||||||||||:||||::|||.|.||||||||||||
Zfish   556 FCQCDRECQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCMTCGAADHWDSKQVSCKNCSIQRGL 620

Human   618 KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVV 682
            ||||||||||||||||||||.||||||||||||||||||||||||::||||||||||||||||||
Zfish   621 KKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQDEADRRGRIYDKYMSSFLFNLNNDFVV 685

Human   683 DATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIE 747
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
Zfish   686 DATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQADALKYVGIE 750

Human   748 RETDVL 753
            ||.:::
Zfish   751 REIEIV 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EZH1	NP_001308008.1	EZH2_WD-Binding	45..73	CDD:288468	14/27 (52%)
		SANT	439..480	CDD:238096	31/40 (78%)
		SANT	439..480	CDD:197842	31/40 (78%)
		SET	<469..733	CDD:225491	225/263 (86%)
		SET	619..740	CDD:214614	116/120 (97%)
ezh1	NP_001035072.2	EZH2_WD-Binding	45..73	CDD:288468	14/27 (52%)
		SANT	447..489	CDD:238096	33/41 (80%)
		SET	<476..736	CDD:225491	225/263 (86%)
		SET	622..743	CDD:214614	116/120 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338793
Domainoid	1	1.000	393	1.000	Domainoid score	I4785
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20458
Inparanoid	1	1.050	1000	1.000	Inparanoid score	I2326
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49242
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	O	PTHR45747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.310