DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pak6 and Pak

DIOPT Version :9

Sequence 1:	NP_001028426.2	Gene:	Pak6 / 214230	MGIID:	2679420	Length:	682	Species:	Mus musculus
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	260/826 - (31%)
Similarity:	368/826 - (44%)	Gaps:	197/826 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 RKKK--------------KKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQW------------- 40
            ||||              ..:|.||.|.||:|.||..||...|:|.|:|..|
  Fly    60 RKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQE 124

Mouse    41 -----QNILDTLR--------RPKPVVDPSRITRVQLQPMKTVVRG--SSVPTEGYISGLLNDIQ 90
                 |.:||.|:        ||......:.||......:..|...  ||.||:..:.|..:...
  Fly   125 QKKNPQAVLDVLKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGN 189

Mouse    91 KLSV-ISSNTLRGRSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQ----SEHTDPHGLYLSCNGG 150
            .:.| :.|.||   .|.:...|.:..:|| :.:.......||..|    ..|...|......:..
  Fly   190 LIGVQLGSMTL---GPNANNVAVAGQILG-NHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSY 250

Mouse   151 TPAGHRQVPWPEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGR 215
            ...||       ..|.....:..|.:...|||...|              |..||   ||:|:
  Fly   251 NFVGH-------TVSSSTSQHSSANEDDMLGPQHPQ--------------QQPPP---PPVAS-- 289

Mouse   216 RGVKVAKHSSEEARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAASSSKP 280
               :..:..|...||...|..:.|..|   .:|:.........||        ||...:|.::.|
  Fly   290 ---RPERTKSIYTRPIEDLQPAIIPMP---VAPATTPATPLQNHR--------TPGGISAPAASP 340

Mouse   281 V-------PLPQNKPNSAFRPPQ----------KDSSSNLVA----KAQSLPSEQPM-------- 316
            :       .|.:||.|:....|.          .|::|.|::    ...:.|:..|.
  Fly   341 MMHNNATTTLDKNKNNATPTSPTTTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSL 405

Mouse   317 ----------------------------------------GTFSPLTT----SDTSSPQKSLRTA 337
                                                    ||...|.|    :.|||.:.|..:.
  Fly   406 VETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSF 470

Mouse   338 PAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGI----------------- 385
            |.|.|||...:|| ||..  |.|.:.:||.| :||||:.:.||..:.:
  Fly   471 PVAVPLPPIVTPA-SPTP--ASIESPDLYTP-EPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAAT 531

Mouse   386 ------------VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKM 438
                        ::.|:....||.:|..|||........|||:|::|.|..|.|..:|.:||:|.
  Fly   532 PNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQ 596

Mouse   439 MDLRKQQRRELLFNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQ 503
            |:|.:|.::||:.||:::||:.:|.|||....||||.|||||:||:|.||:|||::::..::|.|
  Fly   597 MNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQ 661

Mouse   504 IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYW 568
            ||.||..|||||.:|||..|||||||||:|||.|||.|||:|||||||||.:..||.::||||||
  Fly   662 IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYW 726

Mouse   569 MAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKNSYKVSPVLR 633
            |||||::|..|..:||:||||||.||||:|||||.:::|::|:..:..:..|::|...|:|...:
  Fly   727 MAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQ 791

Mouse   634 DFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQT 679
            ||||:.|..|...||:|.:||.||||........|.|||...::.|
  Fly   792 DFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEAT 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak6	NP_001028426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		15/40 (38%)
		PBD	11..63	CDD:334253	23/77 (30%)
		Linker. /evidence=ECO:0000250	26..407		106/515 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..170		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..256		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..367		33/169 (20%)
		STKc_PAK6	386..682	CDD:270821	148/294 (50%)
Pak	NP_001138013.2	PBD	83..137	CDD:279166	18/53 (34%)
		STKc_PAK_I	558..818	CDD:270814	138/259 (53%)
		S_TKc	566..817	CDD:214567	134/250 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920