DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tcf7l2 and pan

DIOPT Version :9

Sequence 1:	XP_006526923.1	Gene:	Tcf7l2 / 21416	MGIID:	1202879	Length:	626	Species:	Mus musculus
Sequence 2:	NP_726528.2	Gene:	pan / 43769	FlyBaseID:	FBgn0085432	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	227/798 - (28%)
Similarity:	321/798 - (40%)	Gaps:	273/798 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 QEEKNSENSSAERDLADVKSSLVNES-----------------ETNQNSSSDSEAERRPPPRSES 74
            :|:||.        |.|:|..|.|.|                 |.|..|:|..|...|   |..:
  Fly   264 REQKNI--------LIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGSNSALEESVR---RQLN 317

Mouse    75 FRDKSRESLEEAAKR------------------------QDGGLFKGPPYPGYPFIMIPDLTSPY 115
            ...||.|:|.|..||                        :||      .|...|...|..|.:..
  Fly   318 GNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDG------EYTSTPTHTIMALAAIA 376

Mouse   116 LPNGSLSP------------------------TARTL-----------------HFQSGSTHYSA 139
            |.|.|:.|                        ..:||                 ...|.||.:.:
  Fly   377 LSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHES 441

Mouse   140 Y-----------------------KTIEHQIAIQYLQMKWPLLDVQAGSLQSRQTLKDARSPSPA 181
            |                       :|..|:..::.......:: ::..||.|...::.:|..:.|
  Fly   442 YSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEII-LEYASLSSSSNIETSRLLTSA 505

Mouse   182 HIVSNKVPVVQHPHHVHPLTPLITYSNEHFT------PGNPPPHLPADVDPKTGIPRPPHPPDIS 240
               ||...|.::.:....|..:..|:.|...      |...|....|...|.||.........:|
  Fly   506 ---SNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGSNSGCSTGMVS 567

Mouse   241 PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSSFLSSRFPPHMVPP 305
            ..:.||.....|          :..:.:..:||..|:     :..:..::.:.::::....  |.
  Fly   568 GIFGLSQNRRKQ----------RLARHIETLTTNSFK-----SNAIRGNVDNEITNQLKTS--PS 615

Mouse   306 HHTLHTTGIPHPAIVTPTVK--------QESS------------QSDVGSL-------------- 336
            ...|.|..:.|  ::|.|:.        ||.|            |.:.||:
  Fly   616 IRALPTENVSH--LITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDL 678

Mouse   337 --------------HSSKHQDSKKEE---EKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAA 384
                          |:|..|.::.:|   :|||||||||||||||||||||||||||||||||||
  Fly   679 SIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAA 743

Mouse   385 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYG---KKKKRKRDKQPGETNEH 446
            ||||||||||.||||||:||||.||:||||||:||||||||||||   ||||||:|:...::..:
  Fly   744 INQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGN 808

Mouse   447 SECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQ---GEGSCLSPPSSD 508
            :                  .||||||||||||:.||.||||||||:||::   |.|     |:.|
  Fly   809 N------------------MKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNG-----PAED 850

Mouse   509 GSLLDSPPPSPH-------------------LLGSPPQDAKSQTEQTQPLSLSLKPDP--LAHLS 552
            ||..|.     |                   ..||..:..|.:.|.::.|:.|: |.|  |:.||
  Fly   851 GSCFDE-----HGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSM-PSPGCLSGLS 909

Mouse   553 MMPPP--------PALLLAEAA-----HGKASALCPNGALDLPPAALQPSMVPSSSLAQPSTSSL 604
            .:..|        |..:.|.:|     ...::||...|| |.|.|..:|::|.:|..:..||||:
  Fly   910 SLQSPSTTMSLASPLNMNANSATNVIFPASSNALLIVGA-DQPTAQQRPTLVSTSGSSSGSTSSI 973

Mouse   605 HSHNSLAGTQPQPLSLVT 622
            .:..:.:.| ..|::.:|
  Fly   974 STTPNTSST-VSPVTCMT 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tcf7l2	XP_006526923.1	CTNNB1_binding	17..259	CDD:369826	62/342 (18%)
Tcf7l2	XP_006526923.1	SOX-TCF_HMG-box	358..425	CDD:238684	61/66 (92%)
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	65/70 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4984
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4297
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm57818
orthoMCL	1	0.900	-	-		OOG6_107890
Panther	1	1.100	-	-	O	PTHR10373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2732
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.750