Protein Alignment Tcf7 and pan

DIOPT Version :9

• Sequence 1: XP_030101626.1
• Gene: Tcf7 / 21414
• MGIID: 98507
• Length: 516
• Species: Mus musculus
• Sequence 2: NP_726528.2
• Gene: pan / 43769
• FlyBaseID: FBgn0085432
• Length: 1192
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 183/585 - (31%)
• Similarity: 241/585 - (41%)
• Gaps: 180/585 - (30%)

Mouse    91 TSQRLFPDKLPESLEDGLKAPECASGMYKET---------VYSAFNLLMPYPPASGAGQ------ 140
            |....:.|.:....|:...||.|.....::|         ..:|..:::.|...|.:..
  Fly   437 TPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRL 501

Mouse   141 --------------HPQPQPPL---HNKPGQPPHGV--PQLSPLYEHFSSPHPTPAPADIS---- 182
                          :...|.|:   :|:.......|  |.|.|   .||:...||:....|
  Fly   502 LTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVP---EFSTAPSTPSTGSNSGCST 563

Mouse   183 -------------QKQGVHRPLQTPDLSGFYS---------------LTSGSMGQLP-------- 211
                         :||.:.|.::|...:.|.|               .||.|:..||
  Fly   564 GMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLI 628

Mouse   212 -HTVSWPSPPL--YPLSPSCGYRQHFPAPTAAPGAP----YPRFTHP-SLMLGSGVPGHPAAIPH 268
             .|:|..:..|  ..||.:..:::...|.....|:.    :|....| .|.:||..........|
  Fly   629 TKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKH 693

Mouse   269 PAIVPSSGKQELQPYDRNLKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAA 333
            .:               |.::....:...:.|||.|||||||||||||||||||:||||||||||
  Fly   694 TS---------------NAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAA 743

Mouse   334 INQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTDPG-- 396
            ||||||||||.||||||:||||.||:||||||:||||||||||||...::.:.|...||||.|
  Fly   744 INQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGN 808

Mouse   397 SPKKCRARFGLNQQTDWCGPCRRKKKCIRYL-------PGE-GRCPSPVPS----------DDSA 443
            :.|||||||||:||:.||.|||||||||||:       |.| |.|.....|          ||..
  Fly   809 NMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDK 873

Mouse   444 LGCPRSPAP-----QDSPSYLLLPSFP----------------TELLASPVE-----------PA 476
            ||.....|.     :|..|..|..|.|                |..||||:.           ||
  Fly   874 LGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSATNVIFPA 938

Mouse   477 ------------------PTF-------SGRSAAL-TLPAPKSPKTPHSTLQNPQIQQQESQRQA 515
                              ||.       ||.:::: |.|...|..:|.:.:..|.:  ..||.:|
  Fly   939 SSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCL--GSSQERA 1001

Mouse   516  515
              Fly  1002  1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tcf7	XP_030101626.1	CTNNB1_binding	20..216	CDD:369826	34/199 (17%)
		SOX-TCF_HMG-box	304..374	CDD:238684	63/69 (91%)
pan	NP_726528.2	SOX-TCF_HMG-box	713..784	CDD:238684	63/70 (90%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4984
eggNOG	1	0.900	-	-		E1_KOG3248
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000839
OrthoInspector	1	1.000	-	-		otm44316
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.960