Protein Alignment EYA3 and eya

DIOPT Version :10

• Sequence 1: XP_011539301.1
• Gene: EYA3 / 2140
• HGNCID: 3521
• Length: 584
• Species: Homo sapiens
• Sequence 2: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 234/601 - (38%)
• Similarity: 313/601 - (52%)
• Gaps: 138/601 - (22%)

Human    16 KAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPM--------SEEIMTCTDYIPRSSNDY--- 69
            |::.:..| |..:.:.|..|:.......|.||| |:        |..:......:....:||
  Fly   209 KSESRSPG-QVHASLDNGSVAGSNLYGCSSASN-PLDGGAVAVNSSAVAAAAAAVYDGKHDYYYY 271

Human    70 -TSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPES 133
             :.|.|:..|:            |.|   |.|     |||....|.|       ..:.||....:
  Fly   272 NSMQQYTPPPF------------YSG---YGT-----PYAAATAARQ-------AKMEPGAAAAA 309

Human   134 GLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQD 198
            ....|||                      |:    ||..|.|.:.:|      |.|...:...||
  Fly   310 AAYLTPS----------------------YA----ASGNNNSQLYSS------PYAGYNNFGQQD 342

Human   199 Y---------PTYTILGQNQYQACYPSSS------FGVTGQTN-----SDAESTT-LAATTYQSE 242
            |         ..|:....:.|....||||      |.|...:|     :|..||| :..||:...
  Fly   343 YGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPH 407

Human   243 KP---------------SVMAPAPAAQRLSSGDPSTSP------SLSQTTPSKDTDDQSRKNMTS 286
            .|               :|.|.|.||...|||..|...      :.|:|||:         ..|.
  Fly   408 SPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPT---------GKTG 463

Human   287 KNRGKR-------KADATSSQDSEL----ERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIG 340
            :.||:|       ::.|:.:.:||.    ||||:||||||:||||:||:||||.:|.||.:.::.
  Fly   464 RARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMT 528

Human   341 SGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGS-- 403
            ....||||:|.:||||.|||::|||||||::||:|||||||||.|:|:||||..:...|:..:
  Fly   529 IAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLC 593

Human   404 -SVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALK 467
             ..||:|||||||||||||||:::||:.::.|||.||.|.::||..::|:||||.||:|...|||
  Fly   594 LPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALK 658

Human   468 SLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKV 532
            .|.:|..|:||||||:|:|||.||||||||:|||.||.|||||||.|||.|:|:||||:|||:|.
  Fly   659 CLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKS 723

Human   533 TYVVIGDGRDEEIAAK 548
            ||||||||.:||.|||
  Fly   724 TYVVIGDGNEEETAAK 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EYA3	XP_011539301.1	HAD_Eya	304..549	CDD:319789	157/252 (62%)
eya	NP_723188.1	HAD_Eya	492..766	CDD:319789	157/248 (63%)