DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALCAM and alcam

DIOPT Version :9

Sequence 1:	NP_001618.2	Gene:	ALCAM / 214	HGNCID:	400	Length:	583	Species:	Homo sapiens
Sequence 2:	XP_012812768.1	Gene:	alcam / 780210	XenbaseID:	XB-GENE-491704	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	573	Identity:	328/573 - (57%)
Similarity:	431/573 - (75%)	Gaps:	8/573 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    11 LLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTK 75
            |:.|:|.:||: |.|.|.:|||:.||:||||||..:...:|:|..|||:..||:..|:|.||:.|
Frog     9 LVVCVLCAATL-RTGFGLHTVNAVYGETIIIPCGHETIDDLLFASWKYDAHDGTSQFLASRSAVK 72

Human    76 KSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIV 140
            ....|.|..|||:|:.:||||||.|:||.|:||:|||||.||.|||||.|.:|:|||..|||||:
Frog    73 NKTTYGDALEYKNRVEVSENYTLFIANAVINDERRFVCMRVTADNVFEDPAVVRVFKPASKPEIL 137

Human   141 SKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTL 205
            .:...:||.::.::|.|:::|||||||||||||||:|.|::|||:|.:.||.:..:.||:|.|:|
Frog   138 EQPKIMETGKINRVGVCVAKDSYPDGNITWYRNGKILLPIDGAVIIDWNKENNSSSGLYSMQSSL 202

Human   206 EYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKC 270
            .|..||.||:..|:|:||::.|:||.:..|:.|.||||||||:||||:.|.|..|||||||||:|
Frog   203 HYMATKEDIRAIFSCTVTFFMPNGQVSAVSDTASFDIYYPTEKVTIQIQPSKKYIKEGDNITLQC 267

Human   271 LGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLS 335
            .|||||||:|||:|||||.|||.||:.|.:||::|||||||||||.| |:|:|||.:|||||||:
Frog   268 RGNGNPPPQEFLYYLPGQEEGIVSSSAYHITDIKRNATGDYKCSLSD-KNMMASTTVTVHYLDLA 331

Human   336 LNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVE 400
            |.||||||:||||...|.|...||:|.:|::|||:..|.:.| |.:|.|:|:|.|.|...|:| |
Frog   332 LTPSGEVTKQIGDTFSVLCVPFASKNVSVMFMKDSKILTALP-FKNLQYRDSGVYECLANLEE-E 394

Human   401 GLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYI 465
            |||.|::|.|.|||||::|::|.....|.:|||...|||||||.:..:.||:...:|:|:|:...
Frog   395 GLKSRKTLKLTVEGKPRLKLSKTPSSDGKTKTISYEVEGFPKPEVSCSSTGNLVHLNKTDETVIS 459

Human   466 NGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIV 530
            |.||.:|||||||||.|:.|.|||:|.:.|.:||||||||||.||.::.||::    :|.|||||
Frog   460 NIRYSAKIIISPEENTTVICVAENKLGKEVRTLNVSAISIPERDEQNDSSDDS----SDHAKLIV 520

Human   531 GIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA 583
            |||||||||||||||.|.:|::||...:|||.|:|||.||||||||||||:||
Frog   521 GIVVGLLLAALVAGVAYCIYIRKSSPGTKHVGKELGNTEENKKLEENNHKSEA 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALCAM	NP_001618.2	Ig strand A'	29..33	CDD:409353	2/3 (67%)
		IGv	38..113	CDD:214650	38/74 (51%)
		Ig strand B	38..46	CDD:409353	6/7 (86%)
		CDR1	47..53	CDD:409353	1/5 (20%)
		FR2	54..60	CDD:409353	3/5 (60%)
		Ig strand C	55..60	CDD:409353	3/4 (75%)
		CDR2	61..78	CDD:409353	7/16 (44%)
		Ig strand C'	68..73	CDD:409353	2/4 (50%)
		Ig strand C'	75..79	CDD:409353	1/3 (33%)
		FR3	79..115	CDD:409353	22/35 (63%)
		Ig strand E	95..102	CDD:409353	5/6 (83%)
		Ig strand F	109..117	CDD:409353	5/7 (71%)
		Ig strand A	128..132	CDD:409353	2/3 (67%)
		C2-set_2	137..231	CDD:400489	46/93 (49%)
		Ig strand B	143..160	CDD:409353	4/16 (25%)
		Ig strand C	166..171	CDD:409353	4/4 (100%)
		Ig strand C'	175..179	CDD:409353	2/3 (67%)
		Ig strand D	187..190	CDD:409353	0/2 (0%)
		Ig strand E	199..207	CDD:409353	4/7 (57%)
		Ig strand F	217..224	CDD:409353	3/6 (50%)
		IG	255..329	CDD:214652	52/73 (71%)
		IG_like	339..393	CDD:214653	26/53 (49%)
		Ig strand C	363..367	CDD:409353	1/3 (33%)
		Ig strand F	389..393	CDD:409353	1/3 (33%)
		Ig_3	415..489	CDD:404760	35/73 (48%)
		Ig strand B	432..435	CDD:409353	2/2 (100%)
		Ig strand C	444..448	CDD:409353	0/3 (0%)
		Ig strand E	471..475	CDD:409353	2/3 (67%)
		Ig strand F	482..487	CDD:409353	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..583		16/20 (80%)
alcam	XP_012812768.1	Ig	134..234	CDD:386229	48/99 (48%)
		IG_like	252..326	CDD:214653	53/74 (72%)
		IG_like	335..406	CDD:214653	36/72 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I9926
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1229
Inparanoid	1	1.050	649	1.000	Inparanoid score	I5874
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189997at7742
OrthoFinder	1	1.000	-	-		FOG0009392
OrthoInspector	1	1.000	-	-		oto148700
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5926
SonicParanoid	1	1.000	-	-		X7130
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090