DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	152/539 - (28%)
Similarity:	248/539 - (46%)	Gaps:	78/539 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 VTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPF-VGNLMFFRQG--FWESQLELRERY----G 75
            |.||:..||:..|:..:.:|...:.|| ..:|:.| |||:..||:.  |.:....:.|::    .
  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGI-GSEPARFPVGNMEGFRKNKHFIDIVTPIYEKFKGNGA 68

Mouse    76 PLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNR-MASGLEPKMVADSVLLLRDRRWEEVRGAL 139
            |..|:::..|..|::::.::.||:|:::|:||.:| |........:...:..:...:|..:|..:
  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANFEDRGMYHNERDDPLTGHLFRIDGPKWRPLRQKM 133

Mouse   140 MSSFSPEKLDEMTPLISQACELLVAHLKRYA--ASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQ 202
            ..:|:..|:..|.|.:.:..|.|.......|  |......|......||.||:...|||.:.:..
  Fly   134 SPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVECNGL 198

Mouse   203 NSPEDPFV----------QHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKN-RDELNGFFN 256
            .:||..|.          :||:....|         |.|||.:    ||.|..:. ..::..|:.
  Fly   199 RNPEAEFAIMGRRAFSERRHCKLVDGF---------IESFPEV----ARFLRMRQIHQDITDFYV 250

Mouse   257 TLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTS 321
            .::|..:..|::|...  |.||:.:::                            |..||
  Fly   251 GIVRETVKQREEQGIV--RSDFMNLLI----------------------------EMKQR----- 280

Mouse   322 TSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAP-EYHS 385
              ...|::|:..|||:|..||.:...:||.|..|.||..|..|.:|.:|:|..:..|... .|.|
  Fly   281 --GELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQAKLREEIDQALRLHNGEFTYDS 343

Mouse   386 LQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQR---IPAGTVLEIAVGALHHDPEHWPN 447
            :|| |.|:::||:||||.||...:.||.:.......|.|   |..|.:|.|.|..:||||..:|.
  Fly   344 MQE-LRYMELVIAETLRKYPILPQLTRISRHLYAAKGDRHFYIEPGQMLLIPVYGIHHDPALYPE 407

Mouse   448 PETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPL 512
            |..|.||||.|:...||....:||||.|||:|:|:|.|.:...:.::.:|..|.|...|.|...:
  Fly   408 PHKFIPERFLADQLAQRPTAAWLPFGDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKI 472

Mouse   513 Q-LESKSALGPKNGVYIKI 530
            : |:|...|.|.||:|:|:
  Fly   473 EFLKSNILLCPANGIYLKV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	141/506 (28%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	142/506 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130979
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820