DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	144/566 - (25%)
Similarity:	237/566 - (41%)	Gaps:	112/566 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 IVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPS-----PFVGNLMFFRQGFWESQLELRERY 74
            ::.:.||:|.:.||..|....||..::.|.    ||     ||         |..||..:.:..:
  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRKGF----PSTGVSIPF---------GALESVTKGKRSF 52

Mouse    75 G------------PLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGL------EPKMVA 121
            |            |:.|.||..|..:::.:..:...|||::|::|.:|   |:      :|  ::
  Fly    53 GMAIYDMYKSTKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDR---GVYVDEKNDP--MS 112

Mouse   122 DSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDA--FNIQRCYCC 184
            .|:..:....|..:|..|..||:..||..|........:.||..:::...:..|  ..:::....
  Fly   113 ASLFQMEGASWRALRNKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMAT 177

Mouse   185 YTIDVVASVAFGTQVDSQNSPEDPF------------VQHCRRASTFCIPRPLLVLILSFPSIMV 237
            |.||::|:..||..|||...|.:.|            ....|..|:|..|        ......|
  Fly   178 YAIDIIATTIFGLDVDSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYP--------GLEKFFV 234

Mouse   238 PLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPE 302
            .:..      :.|.......|....:.||:|....  |:|.||::|..::       :|.....:
  Fly   235 KIGW------KQEATERMRELSNRTVDLREQNNIV--RKDLLQLLLQLRN-------QGKINTDD 284

Mouse   303 SLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERL 367
            ::.|:|.||         :..|..:.|.|.||.|||.:||:|...:|.||..|.|..:|:..|:.
  Fly   285 NIWSAESTK---------NGVKSMSKDLIAGQLFLFYVAGYETTASTTSFTLYELTQNPEVMEKA 340

Mouse   368 LKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQR--IPAGTV 430
            .::|...:.||.....:.....:.||:..|.||.|.||......|...:|..|...:  |..||.
  Fly   341 KEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALPLLNRICTKDYPVPDSKLVIQKGTP 405

Mouse   431 LEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFT---YLPFGAGPRSCLGVRLGLLVVKLT 492
            :.|::..:|.|.|::|:|..:.|||:....    :.:|   |||||.|||.|:|.|:|.:.||:.
  Fly   406 IIISLIGMHRDEEYFPDPLAYKPERYLENG----KDYTQAAYLPFGEGPRMCIGARMGKVNVKIA 466

Mouse   493 ILQVLHKFRFEASPET--------QVPLQLESKSALGPKNGVYIKI 530
            |.:||..|..|...|.        .:||.        ||:||.:::
  Fly   467 IAKVLSNFDLEIRKEKCEIEFGVYGIPLM--------PKSGVPVRL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	135/530 (25%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	119/452 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820