DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbxas1 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	173/558 - (31%)
Similarity:	277/558 - (49%)	Gaps:	82/558 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 VTVTLLVALLALL--KWYSMSAFSRLEKLGIRHPKPSPFVGNL----MFFRQGFWESQLELRER- 73
            |.:::.||.:.||  || |:..|....|.|:.|.||.|.:||:    :..::.:.:..::|..|
  Fly     4 VELSIFVAFIGLLLYKW-SVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRL 67

Mouse    74 -----YG------PLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNR---MASGL-EPKMVADS 123
                 ||      ||  |||        |:|::|:||.::||..|:|.   :..|. :..:::.|
  Fly    68 KQHKVYGVFNLRDPL--YYL--------SDPELIRQVGIKNFDTFTNHRKGITEGFNDTSVISKS 122

Mouse   124 VLLLRDRRWEEVRGALMSSFSPEKLDEMTPLIS----QACELLVAHLKRYAASRDAFNIQRCYCC 184
            :|.||||||:::|..|..:|:..|:.:|..||.    :|.:.:...|.   |......::..:..
  Fly   123 LLSLRDRRWKQMRSTLTPTFTSLKIRQMFELIHFCNVEAVDFVQRQLD---AGTSELELKDFFTR 184

Mouse   185 YTIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLI-LSFPSIMVPL-ARILPNKN 247
            ||.||:|:.|||.||:|...|.:.|....:|.|.|.....|.|:: :..|.:|..| ..::...|
  Fly   185 YTNDVIATAAFGIQVNSFKDPNNEFFSIGQRISEFTFWGGLKVMLYILMPKLMKALRVPVMDMNN 249

Mouse   248 RDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKE 312
            .|    :|..|:...:..|.:|:..  |.|.:.::::||....:          |...|:|...:
  Fly   250 VD----YFKKLVFGAMKYRKEQSIV--RPDMIHLLMEAQRQFKA----------EQEGSAESAAQ 298

Mouse   313 PPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKE---VDLF 374
                    .....|..|:::.|..||..||.|.:...|||.:|.|..:|:.||:||.|   |...
  Fly   299 --------QDKAEFNDDDLLAQCLLFFSAGFETVATCLSFTSYELMMNPEVQEKLLAEILAVKEQ 355

Mouse   375 MGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQ------RIPAGTVLEI 433
            :|:.|. :|.:|. |:.||:.|:||:||.:||||...|....|.::..:      .:....::.|
  Fly   356 LGEKPL-DYDTLM-GMKYLNCVVSESLRKWPPAFIVDRMCGSDFQLKDEEGEVVVNLREDDLVHI 418

Mouse   434 AVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLH 498
            .||||||||:::|.||.|.||||..|.:.:.|.|||||||.|.|||:|.||.|:.||..|.|::
  Fly   419 NVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLPFGVGQRSCIGNRLALMEVKSLIFQLV- 482

Mouse   499 KFRFEASPETQVPLQLESKSA---LGPKNGVYIKIVSR 533
             .|:...|..:.|..:.|..:   |.|:...:.|:.||
  Fly   483 -LRYHLKPTDRTPADMMSSISGFRLLPRELFWCKLESR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	158/518 (31%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	158/517 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.700