DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbxas1 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	140/534 - (26%)
Similarity:	256/534 - (47%)	Gaps:	42/534 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 TVTLLVALLALLKWYSMSAFSRLEKLGI-RHPKPSPF--VGNLMFFRQGFWESQLELRERY-GPL 77
            |:.|.:.:..||..|....::..::||: ..|...||  :..:|...:....:..::..|: |.:
  Fly     3 TILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGKI 67

Mouse    78 CGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPK-MVADSVLLLRDRRWEEVRGALMS 141
            .|.|:..:..::|.:..:.:|::..:|::|.:|.....|.| .::.::..||...|..:|..|..
  Fly    68 VGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKLTP 132

Mouse   142 SFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPE 206
            |||..|:..|...|....:.||.||:......|...|:.....|.:|::.||.||.::||..:|:
  Fly   133 SFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSVIFGLEIDSFRNPK 197

Mouse   207 DPFVQHCRRASTFCIPRPLLVLILSFPSIMV--PLARILPNKNRDELNGFFNTLIRNVIALRDQQ 269
            :.|    |..|:.......|:|.:...|:.:  |:|:::   ||........|.:|:::. |..:
  Fly   198 NEF----REISSSTSRDESLLLKIHNMSMFICPPIAKLM---NRLGYESRILTSLRDMMK-RTIE 254

Mouse   270 AAEER---RRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEI 331
            ..||.   |:|.||:::..::: ..:| |..|.|.:..::.|             ..|..::::|
  Fly   255 FREEHNVVRKDMLQLLIRLRNT-GKIG-EDDDQVWDMETAQE-------------QLKSMSIEKI 304

Mouse   332 VGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKH---PAPE--YHSLQEGLP 391
            ..|||||.:||.|......:|..|.|:.:|:..:...:|||..:.||   |...  |.::|: |.
  Fly   305 AAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQD-LK 368

Mouse   392 YLDMVISETLRMYPPAFRFTREAAQDCEVLGQR--IPAGTVLEIAVGALHHDPEHWPNPETFDPE 454
            :||:.|.||:|.||......||..:|..|.|..  |..||.:.|::..:..||.::|||..:||.
  Fly   369 FLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPH 433

Mouse   455 RFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSA 519
            ||.:. .:......|:|||.|||.|:.:|:|.:..|:.:.::|..|....||..:|..:.::...
  Fly   434 RFDSN-NMNYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPV 497

Mouse   520 LGPKNGVYIKIVSR 533
            |..|..:.:::..|
  Fly   498 LVTKEPLKLRLTKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	132/496 (27%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	127/465 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820