DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbx4 and byn

DIOPT Version :9

Sequence 1:	NP_035666.2	Gene:	Tbx4 / 21387	MGIID:	102556	Length:	552	Species:	Mus musculus
Sequence 2:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	168/598 - (28%)
Similarity:	249/598 - (41%)	Gaps:	169/598 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    41 GLSGAAL-----SSPPGQGADVAAAAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRR 100
            ||.|.|.     :|..|.|.......|.:..:...|:::.|.::|||.:|.....|||:||.|||
  Fly    51 GLGGVAAVSGGGASVSGNGGHRVVGGAGSPNELDRNLRISLDDRELWLRFQNLTNEMIVTKNGRR 115

Mouse   101 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAH 165
            |||..|:..:|::|...|.:|::.|..|.||:|:.:.:|:..||||......:||||:||..|||
  Fly   116 MFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNPIYVHPESPNFGAH 180

Mouse   166 WMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFI 230
            ||::.:||.|:||||. .:..|.|:|||:|||:||:|:|:.      ||:.....|:.||||.||
  Fly   181 WMKEPISFAKVKLTNK-TNGNGQIMLNSLHKYEPRVHLVRV------GSEQRHVVTYPFPETQFI 238

Mouse   231 SVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLVSSQLSAKPDV 295
            :||:|||.::|.|||:.|||||.|            |.:||                    :||.
  Fly   239 AVTAYQNEEVTSLKIKYNPFAKAF------------LDAKE--------------------RPDT 271

Mouse   296 SPLHSAHQAL-----QHYQYENGAHMQFAAAEPQDLPLNTFPTQRDSSLFYHCLKRRDSARHLDL 355
            ...|..|...     .||.....|    .||.|   ||:   ..:...|...| ....||..:.
  Fly   272 LYPHDTHYGWLIPPPTHYTAAAAA----VAAPP---PLS---IAQSHGLVASC-PSVSSAESVG- 324

Mouse   356 PCKRSYLETPSSVGD-DHYFRSPPPYDQQMLSPSYCSEVT-PREACMYSSSGPEIAGVSAVDDLP 418
                     |||.|. |.|.||   ...:.::|:..:..: ||   :.|.||...:..:|....|
  Fly   325 ---------PSSGGSCDRYGRS---LSSRSVAPTRTTPYSRPR---VVSGSGSNGSAGNASSTSP 374

Mouse   419 PPP------------LSCNMWTSVS----------PYT-----SY------SVQTMETVPYQPFP 450
            .||            .:.::.||||          |.|     ||      ||....|.....:|
  Fly   375 QPPSAPQTPTSLHSTSTGSVSTSVSSSSGGGIGSAPSTGCFSSSYAQSGFMSVDASPTASVFSYP 439

Mouse   451 A-------HFTATTVMPRLP-------TIAAQSAQPPGNA------------------HFSVYNQ 483
            :       ::.||:|...:|       .|::.::..|.|.                  |...||
  Fly   440 SSWQSNGNYWNATSVPGPMPMNVCSGRNISSHNSPSPTNGSPSYTTSSPSYTIHHLTPHSHQYN- 503

Mouse   484 LSQSQVRERG------------PSASFPRERGLPGMCERKPPSPHLNTANEFLYSQSFSLTRESS 536
            ::|:.:...|            |.|::       |....:...|...:....||:.:. |...|:
  Fly   504 MAQTDIYGTGVGVGGGAGTTGSPQAAY-------GAAAHQVYHPTPTSPTHQLYTNAV-LNAPSA 560

Mouse   537 LQY-----HSGMG 544
            |.|     |:|.|
  Fly   561 LSYSASGWHNGSG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbx4	NP_035666.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		4/13 (31%)
Tbx4	NP_035666.2	TBOX	71..260	CDD:238106	86/188 (46%)
byn	NP_524031.2	TBOX	86..268	CDD:238106	89/220 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810