DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbx3 and bi

DIOPT Version :9

Sequence 1:	NP_035665.2	Gene:	Tbx3 / 21386	MGIID:	98495	Length:	741	Species:	Mus musculus
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	305/836 - (36%)
Similarity:	392/836 - (46%)	Gaps:	231/836 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 AYHPFLPHRAPDFAMSAV---------------LGHQ-----------PPFFPALTLPP-NGAAA 53
            ::||...|.:|....:|.               |..|           ||:|||..|.. .|:.|
  Fly   195 SHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPA 259

Mouse    54 LSLPGAL-------------AKPIMDQLVGA---AETGIPFSSLGPQAH--LRPLKTMEPEED-V 99
            ...||..             |.|....|..|   ||..:..|::..|.|  :|||:.::||:| |
  Fly   260 GPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGV 324

Mouse   100 EDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYK 164
            .|||||.||.|:||::|||.|||||||||||:|||..|.|.||||.|||||||:||:||||.|||
  Fly   325 VDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYK 389

Mouse   165 FHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHAT 229
            |||||||||||||||||||||||||||.||||||.|||:||||||||||||||||.
  Fly   390 FHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFV--------- 445

Mouse   230 WQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKI 294
                    :.||||||||||||||:|||||||||||||||||:|.||||||||||||:|||||||
  Fly   446 --------STTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKI 502

Mouse   295 DNNPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVG 359
            |||||||||||||.|:|||::  .|.|.|..:.  .|......||.:|..: ...|..|
  Fly   503 DNNPFAKGFRDTGAGKREKKQ--ALMSNRGSDS--DKLNPTHVSSSRAPLH-LGHAGRP------ 556

Mouse   360 TSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARD 424
                ..|.|..|..|    ::::...:..|..              |.|  ::.|.|...|..:.
  Fly   557 ----PHLHPHAALLD----NQQDDDDKLLDVV--------------GPP--QSPLLPLSHSLQQM 597

Mouse   425 TARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARA--IPAKDAF-----APL 482
            .|.        :||.|..:....:.||         |..|::...|.|  ..|:||.     |..
  Fly   598 HAH--------QHSAALAAWFNHLAGA---------GAGASEHAAAAAANASAEDALRRRLQADA 645

Mouse   483 SVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGA 547
            .|:.|.:.......:.|                         :.||||...:.|
  Fly   646 DVERDGSDSSCSESVGG-------------------------STGGAFRPTSTG----------- 674

Mouse   548 STGVSGLESTAMASAAAAQGLS--GAS------AATLPFHLQQHVLASQGLAMSPFGSLFPYPYT 604
                |..|:...|:||||.||:  |.|      :...|.|...|:|.    .:.|.| |:|.|:.
  Fly   675 ----SPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLP----YLYPHG-LYPPPHL 730

Mouse   605 YM----AAAAAASTAAASSSVHRHPFLNLNSMRPRL----------------------RYSPYSI 643
            .:    |||||.|.|..:..:..:..|.|.:..|.|                      |:||||:
  Fly   731 GLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSL 795

Mouse   644 PVPVPDSSSLLATALPSMASAAG-PLDGKAAALAASPASVAVDSGSELNSRSSTLSSGS------ 701
            |..:  .|:..|....|.|:.:| |..|....|...    .|::|....|.|......|
  Fly   796 PGSL--GSAFDAVTPGSNANRSGDPPGGGGGGLGGG----VVENGPRSLSSSPRPRPASHSPPTR 854

Mouse   702 -VSLSPKL----------------CSEKEAATSELQSIQRLVSGLEAKPDRSCSGS 740
             :|:||..                .::.:.:.|||:|::::|:|||.:.:.|.:.:
  Fly   855 PISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbx3	NP_035665.2	T-box	105..305	CDD:366363	157/199 (79%)
		TBX	323..402	CDD:372213	12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..469		16/99 (16%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	14/57 (25%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	157/199 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1117
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1897
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm42683
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850