DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbx2 and Doc1

DIOPT Version :9

Sequence 1:	NP_033350.2	Gene:	Tbx2 / 21385	MGIID:	98494	Length:	711	Species:	Mus musculus
Sequence 2:	NP_648283.1	Gene:	Doc1 / 39039	FlyBaseID:	FBgn0028789	Length:	391	Species:	Drosophila melanogaster

Alignment Length:	330	Identity:	145/330 - (43%)
Similarity:	196/330 - (59%)	Gaps:	48/330 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse   109 LEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWM 173
            ||..:||.||||:||||:||||||||||..:|.:|||:::|.|.:|:::|...||||||..|:|:
  Fly    63 LENNDLWQQFHKIGTEMIITKSGRRMFPSMRVSLSGLEEEASYCVLLEMVPIGDCRYKFSGSQWV 127

Mouse   174 VAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR 238
            .||.|:|:.|:|||:||||||||..|.::.:.|:|:|||||..|..|..:|.||||||||.||:|
  Fly   128 PAGGAEPQSPQRMYLHPDSPATGAHWQSQALLFNKVKLTNNTLDSSGHIVLASMHKYQPRLHIIR 192

Mouse   239 ANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPT 303
            ::::.:||::..:.:|||||:|:||||||||:||:|||||||||||||::|..|. |||..:...
  Fly   193 SSELTQLPWAPQQAFVFPETEFVAVTAYQNDRITKLKIDNNPFAKGFRESGQSRC-KRKLNSSGN 256

Mouse   304 LRLYEEHCKPERDGAESDASSCDPPPAR------EPPPSPSAAP-------------SP-LRLHR 348
            ..|     :.|.||  |..||||.|.|:      |...:.|.:|             || ||.|.
  Fly   257 STL-----ESEDDG--SSVSSCDSPQAKRQRQDFEQDSTGSVSPAYYGATHPVANPMSPYLRHHL 314

Mouse   349 ARAEEKPGAADSDPE----------------PERTGEERSA--APLGRSPSRDASPARLTEPERS 395
            :....  |||...|.                |..|.....|  :|:...|...::|.....|..|
  Fly   315 SYGPS--GAAGLPPSIAAAYFGGVPPQILPMPPATYAPTVAPVSPVASQPVGSSTPTTSPRPSTS 377

Mouse   396 RERRS 400
            .:|.|
  Fly   378 TKRNS 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbx2	NP_033350.2	TBOX	104..289	CDD:238106	107/179 (60%)
		TBX	305..382	CDD:204975	28/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..449		32/126 (25%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..687
Doc1	NP_648283.1	TBOX	58..245	CDD:238106	108/181 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840