Protein Alignment Tbx2 and org-1

DIOPT Version :10

• Sequence 1: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Sequence 2: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 203/629 - (32%)
• Similarity: 275/629 - (43%)
• Gaps: 147/629 - (23%)

Mouse    55 PGLAGAAAAAAAAAAAAEAGLHVSALGPH------------PPAAHLRSLKSLEPEDEVEDDPKV 107
            |...|.|....:|...:.:.......|.|            .|.:|..|....||.........|
  Fly   134 PTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIV 198

Mouse   108 TLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYK--FHNS 170
            .||.|.||||||..||||:|||:||||||.|:||:.|||..|.||.:||.|..||.||:  ||||
  Fly   199 VLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNS 263

Mouse   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235
            .|:|||||||..|.|:::||||||.|..||.:.|:|.|||||||..|::|..||||||:||||||
  Fly   264 CWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFH 328

Mouse   236 IVRANDILKLP-----------YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289
            :|      .||           .|.|||::||||.|.|||||||.::|||||.:|||||||||.|
  Fly   329 LV------YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDG 387

Mouse   290 NGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEK 354
            .      ..:|              ..|..|.:|......||            ::..:.:.:::
  Fly   388 T------NDVT--------------TGGGSSMSSMSHESQAR------------MKQQQQQQQQQ 420

Mouse   355 PGAADSDPEPERTGEERSAAP--LGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGPF 417
            ........:.::..:||:||.  .|.|.|..|...:..:.::....:.|...|...|.|...
  Fly   421 QQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSP--- 482

Mouse   418 SLRSLEKERPEARRKDEGRKDVGEGKEPSL---------APLVVQTDSASPLGAGHLPGLAFSSH 473
            .|...:.|:...::..:.::...:.::..|         ..|:.|:.:.:..|:.|        |
  Fly   483 DLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQANQQQSLLQQSQNHTQYGSYH--------H 539

Mouse   474 LHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGL 538
            .:..|.     ...||..|....| .|.|.:|.|.....|:||||:|::|           |||.
  Fly   540 AYQAQV-----QSHPLTPHSSSSA-SPPATAAPGASAATAAVAGGAGAAG-----------AGGA 587

Mouse   539 GPAASAASTAAPFPFHLSQHMLASQGIP----MPTFGGLFPYPYTYMAAAAAAA----------- 588
            ..|....|.|         ::.:|.|.|    ...||.:    |.:.|||||||
  Fly   588 TSATQVMSAA---------NIYSSIGQPYAQEQSNFGAI----YHHNAAAAAAAHYHHGHAHGHA 639

Mouse   589 ----------------SALPATSAAAAAAAAAGSLSRSPFLGSA 616
                            ..|..:..|||||...|:...| |.|||
  Fly   640 HSHAHAHAHGPYASAYDKLKVSRHAAAAAYGMGATYPS-FYGSA 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbx2	NP_033350.2	T-box_TBX2_3-like	103..287	CDD:410314	116/196 (59%)
		TBX	305..380	CDD:432659	10/76 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		20/146 (14%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		27/114 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	116/195 (59%)