DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbx2 and bi

DIOPT Version :9

Sequence 1:	NP_033350.2	Gene:	Tbx2 / 21385	MGIID:	98494	Length:	711	Species:	Mus musculus
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	322/840 - (38%)
Similarity:	383/840 - (45%)	Gaps:	270/840 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 AASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPPGALGKPLPDPG--------------- 56
            :|||.| ||.|.|..|....|.  .||.|        |.||.|.|.|.|.
  Fly   187 SASAAA-HPSHHPTAAHHSPST--GAAAP--------PAGATGLPPPTPPHHLQQQQQQQQHPAP 240

Mouse    57 ------LAGAAAAAAAAAAAAEAGLHVSA---LGPHPPAAH------------------------ 88
                  .|.|.||.|.:.|....||:...   ..||.|.||
  Fly   241 PPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAH 305

Mouse    89 -----LRSLKSLEPEDE-VEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDK 147
                 :|.|::|:|||: |.||||||||.|:||::|||||||||||||||:|||..|.||||||.
  Fly   306 QLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDA 370

Mouse   148 KAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLT 212
            |||||||:|||||||.||||||||||||||||||||||||||||||.||||||.|.|:|||||||
  Fly   371 KAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLT 435

Mouse   213 NNISDKHGF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQL 274
            |||||||||   ||||||||||||||:|||||||||||||||||||.||:|||||||||:|||||
  Fly   436 NNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQL 500

Mouse   275 KIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSA 339
            |||||||||||||||.|:|||::.|.             ...|::||..:         |...|:
  Fly   501 KIDNNPFAKGFRDTGAGKREKKQALM-------------SNRGSDSDKLN---------PTHVSS 543

Mouse   340 APSPLRLHRARAEEKPGAADSDPEPERTGEERSAAPLGRSPSRDASPARLTEPERSRERRSPERC 404
            :.:||.|..|                           ||.|..
  Fly   544 SRAPLHLGHA---------------------------GRPPHL---------------------- 559

Mouse   405 SKEPTEGGGDGPFSLRSLEKERPEARRKDEGRKD-------VGEGKEPSLAPLVVQTDSASPLGA 462
                                 .|.|...|..:.|       ||    |..:||:..:.|...:.|
  Fly   560 ---------------------HPHAALLDNQQDDDDKLLDVVG----PPQSPLLPLSHSLQQMHA 599

Mouse   463 -GHLPGL-AFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAM-------------GMGHLL 512
             .|...| |:.:||        .|||.....|....|....|..|:             |.....
  Fly   600 HQHSAALAAWFNHL--------AGAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSC 656

Mouse   513 ASVAGGS----------GSS----GGAGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQ 563
            :...|||          ||.    |.|....||||:.|| |...|...:..| |.|.|.|:|
  Fly   657 SESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGLNPGG-GSYPSPNISVGP-PIHPSPHLL--- 716

Mouse   564 GIPMPTFGGLFPYPYTYMAAAAAAASALP-----------ATSAAAA--------AAAAAGSLSR 609
              |.....||:|.|:..:....|||:|:.           |..|.||        |.||||....
  Fly   717 --PYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPV 779

Mouse   610 SPFLGSARPRLRFSPYQIPVTIPPSTSLLTTGLAAE----------GSKGGN---------SREP 655
            ||..|....  |||||.:|.::..:...:|.|..|.          |..||.         |..|
  Fly   780 SPLQGLKSH--RFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSP 842

Mouse   656 SPLP--------ELALRKVGGPS-----RGALSPSGSA--KEAASELQSIQRLVSGLESQ 700
            .|.|        .:::.....||     ||..:.:|.|  :.:.|||:|::::|:|||.|
  Fly   843 RPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQ 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbx2	NP_033350.2	TBOX	104..289	CDD:238106	165/187 (88%)
		TBX	305..382	CDD:204975	12/76 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..449		19/142 (13%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		34/116 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..687		16/80 (20%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	9/57 (16%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	160/182 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1117
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1897
Isobase	1	0.950	-	0	Normalized mean entropy	S3847
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm42683
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890