DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbx15 and bi

DIOPT Version :9

Sequence 1:	NP_033349.2	Gene:	Tbx15 / 21384	MGIID:	1277234	Length:	602	Species:	Mus musculus
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	207/743 - (27%)
Similarity:	286/743 - (38%)	Gaps:	262/743 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 LSMEALSPAGPL------GDTDDPATH-GLEPHPDSEQSTGSDSEVLTERTSCSFSTHTD--LAS 97
            |:..|.|||||.      |....|..| |..||              ......:::|..|  |||
  Fly   251 LAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPH--------------AHHLGSAYTTAEDVVLAS 301

Mouse    98 GAAGPVPAAMSSMEEIQ-----------VELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKIT 151
            ..|..:..||..:..:|           |.|:..|||::||.:||||:|||:||:|||.|:.:::
  Fly   302 AVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVS 366

Mouse   152 GLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSF 216
            |||...:|.:.:|||..|:  |||.:|:|:|||||.||..:|.|:||||||..:|:.||::||||
  Fly   367 GLDAKAKYILLLDIVAADD--YRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSF 429

Mouse   217 DKLKLTNNELDDQGHI---ILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETVFT 278
            .|||||||..|..|.:   ||:||||||||.|::|   ::|:   ..:|... .:|:.|.||.|.
  Fly   430 HKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVR---ANDI---LKLPYST-FRTYVFKETEFI 487

Mouse   279 TVTAYQNQQITRLKIDRNPFAKGFRDSGR-NRTGLEAIMETYA---------------------- 320
            .||||||::||:||||.|||||||||:|. .|...:|:|....
  Fly   488 AVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGH 552

Mouse   321 FWRPP------------------------------------------------------------ 325
            ..|||
  Fly   553 AGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAG 617

Mouse   326 ----------VRTLTFEDF-----------------TTMQKQQGGSTGTSPTTSSTGTP------ 357
                      ....:.||.                 ::..:..|||||.:...:|||:|
  Fly   618 AGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGA 682

Mouse   358 SPSASSHLLSP----------SCSPPTF---HLAPNTFNVGCRESQLCNLNLSDYP--------- 400
            :.:|::..|:|          |..||..   ||.|..:..|.            ||
  Fly   683 AAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGL------------YPPPHLGLLHN 735

Mouse   401 PCARSNMAALQSYPGLSDSGYNRLQSGTASATQPSETF-----MPQRTP-SLISGIP----TPPS 455
            |.|.:.|:.....|||      ...:..|.|.|....|     ....|| |.:.|:.    :|.|
  Fly   736 PAAAAAMSPAGLNPGL------LFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYS 794

Mouse   456 LPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNAFSLHNPYNLYGY 520
            ||         |.||    |.|..|....||..|...|...||                 .|.|.
  Fly   795 LP---------GSLG----SAFDAVTPGSNANRSGDPPGGGGG-----------------GLGGG 829

Mouse   521 NFPTSPR-LAASPEKLSASQS-------------TLLCSSPSNGAFGERQYLPTGMEHSMHMISP 571
            .....|| |::||....||.|             ..|...|..|..|      .|:..|.|..|.
  Fly   830 VVENGPRSLSSSPRPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAG------AGVAQSQHSPSE 888

Mouse   572 STNNQQATNTCDGRQYGAVPGSASQMSV 599
            ..:.::..|..:.:..|:...:|:.:.:
  Fly   889 LKSMEKMVNGLEVQHNGSAAAAAAALQL 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbx15	NP_033349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..95		14/60 (23%)
		TBOX	113..308	CDD:238106	106/209 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369		12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..444		4/23 (17%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	16/71 (23%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	102/191 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840