DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbr1 and Doc2

DIOPT Version :9

Sequence 1:	NP_033348.2	Gene:	Tbr1 / 21375	MGIID:	107404	Length:	681	Species:	Mus musculus
Sequence 2:	NP_648282.1	Gene:	Doc2 / 39038	FlyBaseID:	FBgn0035956	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	161/481 - (33%)
Similarity:	226/481 - (46%)	Gaps:	84/481 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse   195 TQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILA 259
            |.||:     ::.|.|..||.:||:..|||||||.||||||.:..::|||:..::|.:.::::..
  Fly    52 TLPGV-----EMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPI 111

Mouse   260 DPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQM 324
            ....::|.|.:|||.|.|:.. ...|:|:|||||.|||||..|.|.|.|:|||||  ..:|:|.
  Fly   112 GDCRYKFSGSQWVPAGGAEPQ-SPQRMYLHPDSPATGAHWQAQPILFNKVKLTNN--TLDNSGH- 172

Mouse   325 VVLQSLHKYQPRLHVVEVNEDGTEDTSQ-P-GRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPF 387
            :||.|:|||||||||:.     |.|.:| | ...|.|.|.||:|:|||||||..||:||||:|||
  Fly   173 IVLASMHKYQPRLHVIR-----TADLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPF 232

Mouse   388 AKGFRD--------NYDTIYTGCDMDRL-----TPSPNDSPRSQIVPGARYAMAGSFLQDQFVSN 439
            |||||:        ...:..||.|.|:.     :.|.::|..|....|...|...|.:.|.....
  Fly   233 AKGFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQ 297

Mouse   440 YAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQ-RWFVTPANNRLDFAASAYDTA 503
            ..:.|.:..|.:......|:|||..:.|..       |:|.|. .....|...:...|:|.:  .
  Fly   298 IKRLRSNGSACSLSSSLDDQSVPGASSLAL-------GSPPPHLHSHSHPHPLQARSASSVF--M 353

Mouse   504 TDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWPNS 568
            ..|..|..:||..:        |....||     |:.        .|.:|.||...|  |.:|
  Fly   354 QHFQQNMQSLLRPS--------LVDLACT-----YFG--------RPHEYGGAIQAS--PMYP-- 393

Mouse   569 AAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDL-SDSSWIETPSSIKSIDSSDSGIYE 632
             .||...||..|:.|..          |.|....|   || ||.|..|   .::....|::...|
  Fly   394 -PAAMLQAGLGPHPGLN----------LPPGVSGA---DLISDESGAE---ELELDVGSETSTLE 441

Mouse   633 QAKRRRISPADTPVSESSSPLKSEVL 658
            |:.:.:  |.:.|.:.|.....|.:|
  Fly   442 QSTQEQ--PLEQPSTRSKGFSISAIL 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbr1	NP_033348.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127
		TBOX	203..396	CDD:238106	96/202 (48%)
		T-box_assoc	418..679	CDD:374412	55/243 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..483		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..655		14/58 (24%)
Doc2	NP_648282.1	TBOX	55..242	CDD:238106	97/200 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910