Protein Alignment Tbr1 and H15

DIOPT Version :10

• Sequence 1: NP_033348.2
• Gene: Tbr1 / 21375
• MGIID: 107404
• Length: 681
• Species: Mus musculus
• Sequence 2: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 747
• Identity: 204/747 - (27%)
• Similarity: 275/747 - (36%)
• Gaps: 222/747 - (29%)

Mouse     4 EHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKIT---------RGM 59
            :..:|.:...:....|.||.:.|.....   |.||:.:..::......:...|         ||
  Fly    30 QQIVSAAAAAAANIANGSSHHHHHQNHH---HHHPLNNHHNHNHNQHNISFATDFSIAAIMARG- 90

Mouse    60 TNQSDTDNFPDSKD------SPGDVQRSKLSPVLDGV---------SEL--------RHSFDGSA 101
                  .|.|.|::      ||..|:|.......|.|         ||:        ..:...:|
  Fly    91 ------GNAPSSREPSERSLSPASVERYSGQDADDDVDVDVVDCSDSEMPSATAAAAAAATTAAA 149

Mouse   102 ADRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSR-YMAHHPVITNGAYNSLLSN-- 163
            |...|.:|....|:...|.........|....|...:.|...| :..||...||.:.||..||
  Fly   150 AAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTNNSSNSGNSNTN 214

Mouse   164 ---SSPQG----------YPTAGYPYPQQYGHSYQGAPFYQFSSTQP-----------GLVPGKA 204
               ||.:|          .|:...|.|.|.....:.....:..:.||           .|.|  .
  Fly   215 SKSSSQRGRSAAAVGAAATPSPPPPPPSQSPEELERLSPEESPAQQPTPKIVGSCNCDDLTP--V 277

Mouse   205 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWR 265
            |.:|..:.||.|||...|||||||.||||||.:..:.||    :.|...|.:.:||:..|...:|
  Fly   278 QCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDVVPLDSRRYR 342

Mouse   266 --FQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQ 328
              :....|:..||||. ...:|:|.|||.|.:.....:|.:||.|:|||||:  .:.:|| |||.
  Fly   343 YAYHRSSWLVAGKADP-PPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE--MDKSGQ-VVLN 403

Mouse   329 SLHKYQPRLHVVEVNEDGTEDTSQPGRVQ-----TFTFPETQFIAVTAYQNTDITQLKIDHNPFA 388
            |:|:||||:|:|.::. |......|..:|     ||.||||.|.|||||||..||:||||.||||
  Fly   404 SMHRYQPRIHLVRLSH-GQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKIDSNPFA 467

Mouse   389 KGFRDNYDTIYTGCDMDR-----------LTPSP----NDSPRSQIVPGARYAMAGSFLQDQFVS 438
            |||||:...    .|.||           :..:|    .|...||:.|....|.:.:.|:
  Fly   468 KGFRDSSRL----SDFDRDPMDAFFFDQHMRTAPLRFFPDPLMSQLTPQEADAASMALLE----- 523

Mouse   439 NYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSP-----------QRWFVTPANNR 492
               |||.|... .|..|.|:..:||   |.....|..|..|:|           |:|....|.
  Fly   524 ---KARQHLQM-FGRSPYTEMLLPH---LYQRSAAPPPPPPAPHLSAFQLGMWQQQWPQLTAG-- 579

Mouse   493 LDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAK 557
              |.|||...|                   ||.|.|||..               |:||
  Fly   580 --FLASANQQA-------------------ALALAAAGAN---------------RTPP------ 602

Mouse   558 SGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKS 622
                    |:.|.|                       |.|||                ||:|...
  Fly   603 --------PSMAVA-----------------------PPAPA----------------TPTSSCG 620

Mouse   623 IDSSDSGIYEQAKR--RRISPADTPVSESSSP 652
            ..|.|.....|...  :|.||...|..::|.|
  Fly   621 SASPDLRARPQLNHYPQRFSPYQVPQHQASPP 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbr1	NP_033348.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..83		10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..127		3/18 (17%)
		T-box_TBR1	203..393	CDD:410330	91/200 (46%)
		T-box_assoc	418..679	CDD:465042	54/248 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..483		10/46 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..655		15/58 (26%)
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	92/200 (46%)