DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a6 and List

DIOPT Version :9

Sequence 1:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	183/535 - (34%)
Similarity:	284/535 - (53%)	Gaps:	37/535 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    47 KPPQR--EKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEV 109
            ||.::  |:|.:.::|:.|.....|||||:|||||:.::||||.|:|||.|.|...|.||::||:
  Fly    12 KPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEI 76

Mouse   110 IIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNH 174
            .:||:|..|.:..:: :.||..|:....::..:....||..|:|....:...||..:|||:.|..
  Fly    77 SLGQFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWE 140

Mouse   175 SWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLSLSSGIDNPGSL-KWDLALCLLLVW 238
            ||.| .|.:...:         :::...||...::||.:|.....|||..|| .|.|..||.:.|
  Fly   141 SWGT-DCHDGNAQ---------NSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAW 195

Mouse   239 LVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWID 303
            ||....:.:|::|:||..||...||:.:||:||:|.:|||||.:||.::..|....|.:|.||..
  Fly   196 LVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYA 260

Mouse   304 AGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQG-V 367
            |.||:|||.|||.|.:.:..|||.:..|.|.|.:::..::|.:|.::|...|.|||.:|:|.| .
  Fly   261 AVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNP 325

Mouse   368 DIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSF 431
            ||..|.:.|.|||||:||:|:.... :|..:::|||:||.:||           |.|.|.:....
  Fly   326 DIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLG-----------IGSTVGMGSCI 379

Mouse   432 LRK-----GYRREIFIAI---LCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFV 488
            ||.     |.|......:   |..:.:.:.:..:|.||.::..|.|:|..|...|: :|..|...
  Fly   380 LRVIRDQFGLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALI-LAIGELVA 443

Mouse   489 IAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAI 553
            :|||||.:...:.|:.|:|...|.:.:..|..|||.|.....::.|:....|.|..| .||..|.
  Fly   444 VAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGV-GYPTLAH 507

Mouse   554 GLGWGLALSSMLCIP 568
            ..|..||...::.:|
  Fly   508 VFGCFLATLGLIQLP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	181/531 (34%)
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	170/492 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910