DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tacr2 and TkR86C

DIOPT Version :9

Sequence 1:	NP_033340.3	Gene:	Tacr2 / 21337	MGIID:	98477	Length:	384	Species:	Mus musculus
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	121/344 - (35%)
Similarity:	194/344 - (56%)	Gaps:	26/344 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 FSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN 90
            :.:|..|..:||..:..::.||:.||..|:||:..|..||||||||::||::|||.|::.|..||
  Fly    76 YELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNCVFN 140

Mouse    91 FIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI 155
            ||:..::.|.|||.:|...|......:..|::::.||:.|||:|||||.:.|.|....:.::.:|
  Fly   141 FIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRTSRRKVRIILVLI 205

Mouse   156 WLVALALASPQCFYSTITV-----DQGATKCVVAWPNDNGGKML--LLYHLVVFVLIYFLPLVVM 213
            |.::..|::|...||:|..     .:..|.|.:.||:......:  ..|:|::.||.|.:|::||
  Fly   206 WALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGIPMIVM 270

Mouse   214 FAAYSVIGLTLW-KRAVPRHQAHGAN----LRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
            ...||::|..|| .|::      |.|    :..:::|:|.|:..:.:|..||||||||||:||..
  Fly   271 LICYSLMGRVLWGSRSI------GENTDRQMESMKSKRKVVRMFIAIVSIFAICWLPYHLFFIYA 329

Mouse   274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPT---EEDR 335
            .....:...|::|.:||..:|||||:.|.||:||..:|.|||..|:....||..|...   :..:
  Fly   330 YHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPK 394

Mouse   336 LELTHTPSISRRVNRCHTK 354
            ..||:..|.:|     ||:
  Fly   395 SRLTNKNSSNR-----HTR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tacr2	NP_033340.3	7tm_4	42..>168	CDD:304433	50/125 (40%)
		7tm_1	50..307	CDD:278431	99/268 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..384
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	108/289 (37%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	99/268 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55548
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm8831
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740