DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EXT2 and sotv

DIOPT Version :9

Sequence 1:	XP_011518252.1	Gene:	EXT2 / 2132	HGNCID:	3513	Length:	764	Species:	Homo sapiens
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	714	Identity:	342/714 - (47%)
Similarity:	478/714 - (66%)	Gaps:	29/714 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    62 PRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRS----IRDVPVVRLPADSP 122
            ||   :|.:..:|...:|::.|.|.  |..|..|....:.:...||.    |.|:..::..|.:|
  Fly    22 PR---EHILNCLTYGLLVIVALCAG--FLLWDLSSSPRDGFFHGKRDSHTLILDLEHIQELAVNP 81

Human   123 IPER--GDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISD 185
            ..|:  .:::|....|.::|:|   ..:::|||||.|:::||:.....:.|:|.||.::|.|:..
  Fly    82 EAEQRARNVNCTFWDCLNIYKC---EHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLK 143

Human   186 SDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALD 250
            |.|||.:.|.||||:||:|:||||.........|:|.|..||||.||::|||||||.|.|||.||
  Fly   144 SRYYTSNPNEACLFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPGGAPSYNTVLD 208

Human   251 VPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDL 315
            |..|.|::.||||.:|:||.|:||:|||:||  ..|.........|::.|:.:|:.:.|.:...|
  Fly   209 VNTDNAIIFGGGFDSWSYRPGFDVAIPVWSP--RLVRQHAHATAQRKFLLVVAQLNILPRFVRTL 271

Human   316 EALQVKHGESVLVLDKCTNLSEGVLSVRKRC---HKHQVFDYPQVLQEATFCVVLRGARLGQAVL 377
            ..|.:.|.|.:|:|..|.|     |.:..||   ..|:..:||::|....||::.|..|:||..|
  Fly   272 RELSLAHSEQLLLLGACEN-----LDLTMRCPLSQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDL 331

Human   378 SDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFW 442
            .:::...|:||:..|:|:|||.:|:||..|||.:.|.::..|...|::|...:|.|||:|.:|.:
  Fly   332 VEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLF 396

Human   443 EAYFQSIKAIALATLQIINDRIYPYAAISYEEWN--DPPAVKWGSVSNPLFLPLIPPQSQGFTAI 505
            ..||:.:|.:.|..|:::..||:|..|.|..:||  |..|   .|..||||||.:.|:||||||:
  Fly   397 SKYFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNA---RSTFNPLFLPSLAPKSQGFTAV 458

Human   506 VLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFF 570
            :||||||||||.:|.:::.||||..:||:||||.|:||..|.:|.|..|||:.:|.||||||||:
  Fly   459 ILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRFY 523

Human   571 PYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNE 635
            ||.||||||:|.|||||||||:|||.|||||||||||.:||:|.|:|:|::...:|.|||||||:
  Fly   524 PYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTNQ 588

Human   636 VSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKC 700
            :|||||||||:|||::::||:.||||||:|||.|||||||||||||||:|....|||||||||||
  Fly   589 ISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFKC 653

Human   701 PECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL 764
            ||||..:.||.|..||.|||.||::|:.::|.|||:.||.||||||::|:||:|||.:.:||||
  Fly   654 PECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKRYNDIGSL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EXT2	XP_011518252.1	Exostosin	146..426	CDD:281069	114/282 (40%)
EXT2	XP_011518252.1	Glyco_transf_64	502..736	CDD:286358	156/233 (67%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	114/281 (41%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	156/233 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156685
Domainoid	1	1.000	368	1.000	Domainoid score	I922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H345
Inparanoid	1	1.050	687	1.000	Inparanoid score	I704
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48639
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0008338
OrthoInspector	1	1.000	-	-		oto89803
orthoMCL	1	0.900	-	-		OOG6_106435
Panther	1	1.100	-	-	LDO	PTHR11062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4562
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940