DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EXT1 and sotv

DIOPT Version :9

Sequence 1:	NP_000118.2	Gene:	EXT1 / 2131	HGNCID:	3512	Length:	746	Species:	Homo sapiens
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	236/734 - (32%)
Similarity:	374/734 - (50%)	Gaps:	112/734 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    65 FVPWDQLENEDSSVHISPRQ-----KRDANSSIY------------------KGKKCRMESCFDF 106
            |:.||        :..|||.     |||:::.|.                  :...|....|.:.
  Fly    44 FLLWD--------LSSSPRDGFFHGKRDSHTLILDLEHIQELAVNPEAEQRARNVNCTFWDCLNI 100

Human   107 TLCKKNGFKVYVYPQQK---------GEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLD 162
            ..|:.:..|||:||.|:         ...::..|..||.|:..||:|||:|::||||:.|||.|:
  Fly   101 YKCEHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLKSRYYTSNPNEACLFLPSLDLLN 165

Human   163 RDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFR 227
            ::....   |...:.:.||..|:.|.||:|||:..|..|.|...:..:...|::......:.::|
  Fly   166 QNVFDK---HLAGAALASLDFWDRGANHIIFNMLPGGAPSYNTVLDVNTDNAIIFGGGFDSWSYR 227

Human   228 PNFDVSIPLFS----KDHPRTGGERGFL----KFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALY 284
            |.|||:||::|    :.|.....:|.||    :.|.:|            |::.     |...|.
  Fly   228 PGFDVAIPVWSPRLVRQHAHATAQRKFLLVVAQLNILP------------RFVR-----TLRELS 275

Human   285 HVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLE 349
            ..|: |.::||..|::     .....||.. :..::..:|..:|....|||:.|..|:|....:|
  Fly   276 LAHS-EQLLLLGACEN-----LDLTMRCPL-SQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDLVE 333

Human   350 ALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEA 414
            .:...|:||:..:.:.|||.:||:|:.|:|...|..|..:...:::|...||:.:::|.|:|:..
  Fly   334 IMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLFSK 398

Human   415 YFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNK---------HPGGLFVLPQYSSYLGDFPYYYA 470
            ||..::.:.||.||:::.|||...:|:|..||.         :|  || ||
  Fly   399 YFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNARSTFNP--LF-LP-------------- 446

Human   471 NLGLKPPSK-FTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAK-HRWPATA 533
              .|.|.|: |||||.....:.|....:.||.|..:    ...|:|:||..|..|.. ..:|:.:
  Fly   447 --SLAPKSQGFTAVILTYDRVESLFLLIQKLAVVPS----LQSILVIWNNQKKSPPHLSTFPSIS 505

Human   534 VPVVVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTT-EVDFAFTVWQSFPERIVGYPARSH 597
            .|:.:.:.:...:|:||.||..|.|:|:|::|:|.::.|| |:||.:.||:.||:.|||:|:|.|
  Fly   506 KPLKIRQTKENKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIH 570

Human   598 FWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVS 662
            .|:|...||.|.|:|||..||||||||.:|||:.::|:|.:|..:|:.||:..|||||.|||||:
  Fly   571 VWENVTMRWHYESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVA 635

Human   663 AVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPV 727
            .:|..||||||.:|::|......|...|  ||.:|..:|.:|::.|:..:|.|||...:.|.|||
  Fly   636 NITNNPPIKVTPRKKFKCPECTNTEMLS--ADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPV 698

Human   728 LFKDQVSILRKKYRDIERL 746
            ||:|......|:|.||..|
  Fly   699 LFRDNFPDKLKRYNDIGSL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EXT1	NP_000118.2	Exostosin	110..396	CDD:308581	84/302 (28%)
		Glyco_transf_64	480..725	CDD:312681	101/246 (41%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	544..549		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	565..567		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	650..654		2/3 (67%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	688..701		4/12 (33%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	84/301 (28%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	99/239 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920