DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EWSR1 and TIF35

DIOPT Version :9

Sequence 1:	XP_011528297.1	Gene:	EWSR1 / 2130	HGNCID:	3508	Length:	670	Species:	Homo sapiens
Sequence 2:	NP_010717.1	Gene:	TIF35 / 852039	SGDID:	S000002837	Length:	274	Species:	Saccharomyces cerevisiae

Alignment Length:	175	Identity:	35/175 - (20%)
Similarity:	64/175 - (36%)	Gaps:	53/175 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   295 MSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPV------ 353
            :|..::.....||.:.....:.|:.||.|.:           ||         ...||.
Yeast   130 LSALEDPATNEGGVEAASEEKAGQVGGAGSI-----------PG---------QYVPPSRRAGAR 174

Human   354 DPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQ--------------PMIHIYLD 404
            ||..|:         ..||...||:...    .::::|:...:              |.:.:..:
Yeast   175 DPSSDA---------YRDSRERDDMCTL----KIMQVNENADENSLREELLFPFAPIPRVSVVRN 226

Human   405 KETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKK 449
            |||||.:|.|.|::.....|:.|:.:.||:.:....|:|..::.|
Yeast   227 KETGKSRGLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEWSKPK 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EWSR1	XP_011528297.1	RRM	<351..>459	CDD:223796	26/119 (22%)
		RRM_EWS	362..445	CDD:240977	20/96 (21%)
		zf-RanBP	519..561	CDD:279035
		RanBP2-type Zn finger	523..557	CDD:275375
TIF35	NP_010717.1	eIF3g	6..127	CDD:403535
TIF35	NP_010717.1	RRM_eIF3G_like	192..268	CDD:409842	16/79 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910