Protein Alignment EWSR1 and NRP1

DIOPT Version :10

• Sequence 1: NP_001425429.1
• Gene: EWSR1 / 2130
• HGNCID: 3508
• Length: 670
• Species: Homo sapiens
• Sequence 2: NP_010114.1
• Gene: NRP1 / 851387
• SGDID: S000002326
• Length: 719
• Species: Saccharomyces cerevisiae
• Alignment Length: 255
• Identity: 51/255 - (20%)
• Similarity: 66/255 - (25%)
• Gaps: 119/255 - (46%)

Human   349 LGPPVDPDED------SDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKET 407
            |..|.|...|      ..:..:|:..|....|..:|..:|.|.||
Yeast   207 LTKPYDSHTDIRAFLQEKSKILYMNNLPPDTTQSELESWFTQYGV-------------------- 251

Human   408 GKPKGDATVSYEDPPTAKAAVEW-------FDGKD-------FQ------------GSKLKVSLA 446
             :|.|..||......|:.....|       .:.:|       ||            |..:..:||
Yeast   252 -RPVGFWTVKNIVEDTSNVNNNWSLNNSPYVEDQDSISGFVVFQTHEEATEVLALNGRSILSNLA 315

Human   447 RKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPG---------GPGGPMGRMGGRGGDRGGFPPRG 502
            ..|.|             |.:...|...|...|         .|                ||.
Yeast   316 NTKQP-------------RVVEHVLELQPSSTGVLDKAQEILSP----------------FPQ-- 349

Human   503 PRGSRGNPSGGGNVQHRAGDWQCPNPSIGDFCCDVIVCRGCGNQNFAWRTECNQCKAPKP 562
               |:..|        |.|||.||:               ||..||..||.|.:|..|.|
Yeast   350 ---SKNKP--------RPGDWNCPS---------------CGFSNFQRRTACFRCSFPAP 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EWSR1	NP_001425429.1	None
NRP1	NP_010114.1	RRM_ARP_like	226..328	CDD:409886	23/135 (17%)
		zf-RanBP	355..384	CDD:395516	16/44 (36%)
		RanBP2-type Zn finger	359..378	CDD:275376	10/33 (30%)
		zf-RanBP	581..609	CDD:395516
		RanBP2-type Zn finger	585..604	CDD:275376