DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EWSR1 and ewsr1a

DIOPT Version :9

Sequence 1:	XP_011528297.1	Gene:	EWSR1 / 2130	HGNCID:	3508	Length:	670	Species:	Homo sapiens
Sequence 2:	NP_001108610.1	Gene:	ewsr1a / 323597	ZFINID:	ZDB-GENE-030131-2317	Length:	626	Species:	Danio rerio

Alignment Length:	712	Identity:	399/712 - (56%)
Similarity:	467/712 - (65%)	Gaps:	128/712 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAS-TDYSTYSQAAAQQGYSAYTAQPTQ-GYAQTTQQAYG-QQSYGTYGQPTDVSYTQAQ-TTAT 61
            ||| .||::|.||.:||||.:|.|||:| ||.|.|||:|| ||.||:|.||.|.:|:|.. ::::
Zfish     1 MASAADYNSYGQAGSQQGYGSYPAQPSQPGYGQGTQQSYGQQQGYGSYSQPADSTYSQTSGSSSS 65

Human    62 YGQTAYATSYGQPPT---GYTTPTA-PQAYSQPVQGYGTGAYDTTTA---TVTTTQASYAAQSAY 119
            |||..|.:||||.|.   .|...:| ||.|:|||||||:.:||::||   :.:.||.||..|::|
Zfish    66 YGQQPYGSSYGQQPPASGSYNAASATPQGYTQPVQGYGSSSYDSSTAAASSTSNTQTSYGGQASY 130

Human   120 GTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQP 184
            |||.|||.|||||||.||              |.|.:.|..||: ||.||:||         .||
Zfish   131 GTQSAYPGYGQQPAAAAP--------------PSSYSSGSQQPA-GYEQSSYS---------QQP 171

Human   185 VTAPPSYPPTSYSSTQPTSYDQSSYSQQNT---YGQPSSYGQQSSYGQQSSY-------GQQPPT 239
                                .||:||||..   .||...|||||||.||..|       .|.||:
Zfish   172 --------------------QQSTYSQQQQGGYQGQQGGYGQQSSYSQQGGYQQTPPQQQQAPPS 216

Human   240 SYPPQTGSYSQ-APSQYSQQSSS---YGQQ--------SSFRQDHPSSMGVYGQESGGFSGPGEN 292
            ||.|.:|||.| :.|||.||.|:   |||.        .|:|.||.:..|..|.||||:.||||.
Zfish   217 SYAPPSGSYGQPSASQYGQQGSTGGGYGQSDYKPPNQYGSYRPDHQNGGGYSGPESGGYGGPGEG 281

Human   293 RSMSGPDNRGRGRGGFDRGGMSRGG--RGG-GRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVD 354
            |.|.|.:||||||||||||.|..||  ||| .|||||.||:||||:|||       |.::|.|.:
Zfish   282 RGMGGGENRGRGRGGFDRGMMRGGGGMRGGMSRGGMGIAGDRGGFSKPG-------DGEMGAPEE 339

Human   355 PDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYE 419
            .| ||:||.||:.||.::.||:::|||||..|::::|||||.|.::||.||:|||||||||:|||
Zfish   340 QD-DSENSTIYITGLTENATLEEVADFFKHSGIIRINKRTGLPAVNIYTDKDTGKPKGDATLSYE 403

Human   420 DPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGP 484
            :||:|||||||||||||||.|||||:||:||.|..||||:          |:||..||..|.||.
Zfish   404 EPPSAKAAVEWFDGKDFQGKKLKVSMARRKPMMGMMRGGM----------PMRGDRGGMMGRGGM 458

Human   485 MGRMG-GRGGDRGGFPPR-GPRG-SRGNPSGGGNVQHRAGDWQCPNPSIGDFCCDVIVCRGCGNQ 546
            |||.| |||||||||.|| |||| .||.|: |||:|.|||||||||             .|||||
Zfish   459 MGRGGMGRGGDRGGFMPRGGPRGMGRGGPT-GGNMQQRAGDWQCPN-------------AGCGNQ 509

Human   547 NFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGM--FRGGRGGD 609
            |||||.|||||||||||||.|||| |||||||||||||||||||  ||||||||.  ||||||.|
Zfish   510 NFAWRMECNQCKAPKPEGFGPPPF-PPGGDRGRGGPGGMRGGRG--MDRGGPGGPGGFRGGRGVD 571

Human   610 RGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMD-KGEHRQERRDRPY 670
            ||||| |||||||||||   .|.||||   |:.||.|..|.|.||||| ||:|||:||:|||
Zfish   572 RGGFR-GRGMDRGGFGG---RGRGGPP---MDDMGRRGRGMGPPGKMDMKGDHRQDRRERPY 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EWSR1	XP_011528297.1	RRM	<351..>459	CDD:223796	70/107 (65%)
		RRM_EWS	362..445	CDD:240977	56/82 (68%)
		zf-RanBP	519..561	CDD:279035	26/41 (63%)
		RanBP2-type Zn finger	523..557	CDD:275375	18/33 (55%)
ewsr1a	NP_001108610.1	RRM	<329..>431	CDD:223796	66/109 (61%)
		RRM_EWS	346..429	CDD:240977	56/82 (68%)
		zf-RanBP	495..525	CDD:279035	27/42 (64%)
		RanBP2-type Zn finger	499..520	CDD:275375	18/33 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328890
Domainoid	1	1.000	287	1.000	Domainoid score	I7948
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136069
Inparanoid	1	1.050	696	1.000	Inparanoid score	I4311
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43140
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0007232
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.370