Protein Alignment EWSR1 and ewsr1b

DIOPT Version :9

• Sequence 1: XP_011528297.1
• Gene: EWSR1 / 2130
• HGNCID: 3508
• Length: 670
• Species: Homo sapiens
• Sequence 2: XP_005165164.2
• Gene: ewsr1b / 322880
• ZFINID: ZDB-GENE-030131-1600
• Length: 579
• Species: Danio rerio
• Alignment Length: 700
• Identity: 349/700 - (49%)
• Similarity: 416/700 - (59%)
• Gaps: 151/700 - (21%)

Human     1 MAS-TDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQQAYGQQSYGTYGQPT---DVSYTQAQTTA- 60
            ||| |:||:|:||.|||.|.:|||.|.|.|.||.||.|.||.|.:|.||.   :.:|:||..:|
Zfish     1 MASVTNYSSYNQAGAQQSYGSYTAPPAQTYGQTAQQGYTQQDYSSYAQPAAAPEATYSQAAPSAG 65

Human    61 TYGQTAYATSYGQ-------PPTGYTTPTAPQAYSQPVQGYGTGAYDTTTATVTTTQASYAAQSA 118
            .|.|..|.::|||       .|..|.|| .|.||:||.|.||..:|..:|| ....||||.:|..
Zfish    66 AYAQQQYGSTYGQAAATAAAAPAAYGTP-QPGAYTQPAQSYGASSYTGSTA-APAAQASYGSQPG 128

Human   119 YGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQ 183
            |.|||||..|.|||||:|
Zfish   129 YSTQPAYSGYSQQPAASA----------------------------------------------- 146

Human   184 PVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYG--QQSSYG---------QQP 237
                     |.|||::...:|:||:|||...|.||....||..||  |||:||         |.|
Zfish   147 ---------PQSYSASSQPAYNQSAYSQPAGYSQPGYQAQQPGYGQQQQSAYGQGQPPQQHQQGP 202

Human   238 PTSYPPQTGSYSQAPSQYSQQSSSYGQQSSFRQDHPSSMGVYGQESGGFSG--PGENRSMSGPDN 300
            |.:|||| ||.|.|.:||.|||:   .|:.::|:..:|   |.|  ||.||  ||..|   |...
Zfish   203 PAAYPPQ-GSSSYAQTQYGQQSA---PQNDYQQNPYNS---YSQ--GGVSGGYPGSQR---GGYQ 255

Human   301 RGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIY 365
            .| ||.|:||||..  |||.||||||.||:|||||||||||..|.|.|:|.|  .::||:||.||
Zfish   256 DG-GRDGYDRGGPR--GRGMGRGGMGIAGDRGGFNKPGGPMRGGMDRDMGHP--GEQDSENSTIY 315

Human   366 VQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEW 430
            :.||.::.||.::|:|||..|.:::|:|..||.|:||.||::||||||||:|||:|..||||||.
Zfish   316 ITGLTENATLPEMAEFFKHTGAIRINRRLNQPAINIYTDKDSGKPKGDATLSYEEPAFAKAAVEH 380

Human   431 FDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDR 495
            ||||:|||.:||||:||:||.:..||||:|.|                ||||...|.|.||||:|
Zfish   381 FDGKEFQGRRLKVSMARRKPMIGGMRGGMPMR----------------GGPGMDRGGMMGRGGER 429

Human   496 GGFPPR-GPRGSRGNPSGG---GNVQHRAGDWQCPNPSIGDFCCDVIVCRGCGNQNFAWRTECNQ 556
            |||||| ||||..| .:||   ||||.|||||:|||             .|||||||:||.||||
Zfish   430 GGFPPRGGPRGGMG-WNGGPQPGNVQKRAGDWECPN-------------AGCGNQNFSWRMECNQ 480

Human   557 CKAPKPEGF-LPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMD 620
            ||||||||. ..||| .|||:|||   ||||||||  ||||||||| |||.|||||||||..|||
Zfish   481 CKAPKPEGLGTSPPF-SPGGERGR---GGMRGGRG--MDRGGPGGM-RGGWGGDRGGFRGRGGMD 538

Human   621 RGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGPGKMDKGEHRQERRDRPY 670
            ||||.||.||||.      |::  ||| |.|.||||:..:||||||:|||
Zfish   539 RGGFRGGSRGGPP------MDR--GRR-GMGPPGKMEMRDHRQERRERPY 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EWSR1	XP_011528297.1	RRM	<351..>459	CDD:223796	61/107 (57%)
		RRM_EWS	362..445	CDD:240977	49/82 (60%)
		zf-RanBP	519..561	CDD:279035	24/41 (59%)
		RanBP2-type Zn finger	523..557	CDD:275375	16/33 (48%)
ewsr1b	XP_005165164.2	RRM	<306..>397	CDD:223796	53/90 (59%)
		RRM_SF	312..395	CDD:302621	49/82 (60%)
		zf-RanBP	456..486	CDD:279035	25/42 (60%)
		RanBP2-type Zn finger	460..481	CDD:275375	16/33 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328888
Domainoid	1	1.000	128	1.000	Domainoid score	I21016
eggNOG	1	0.900	-	-		E1_KOG1995
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43140
OrthoDB	1	1.010	-	-		D1539664at2759
OrthoFinder	1	1.000	-	-		FOG0007232
OrthoInspector	1	1.000	-	-		oto45324
orthoMCL	1	0.900	-	-		OOG6_114329
Panther	1	1.100	-	-	O	PTHR23238
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4499
SonicParanoid	1	1.000	-	-		X712
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.250