DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MECOM and egl-43

DIOPT Version :9

Sequence 1:	XP_005247270.1	Gene:	MECOM / 2122	HGNCID:	3498	Length:	1240	Species:	Homo sapiens
Sequence 2:	NP_001022288.1	Gene:	egl-43 / 174552	WormBaseID:	WBGene00001207	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	765	Identity:	186/765 - (24%)
Similarity:	248/765 - (32%)	Gaps:	334/765 - (43%)

- Green bases have known domain annotations that are detailed below.

Human   266 KECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKQVFT 330
            :|||:  .|...||..:|...|:|......|.|:.:..|||                |..::...
Worm    97 EECDE--EDQDDLENLILLKDEDRPDSTQSCTKSSSEDSNL----------------NGFEEYIR 143

Human   331 DPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRH 395
            :...|   :..|.....:|.|..|.|:|:::||||||.|||.|:|||.|.:|.||||||||||||
Worm   144 EHGEL---VPGQTPPDGSHKCGVCPKSFSSASGLKQHSHIHCSLKPFRCHLCPKSYTQFSNLCRH 205

Human   396 KRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNM 460
            :|:|:|..|   |..|.....:.::|.|||..||                   ..|:.|..|..:
Worm   206 RRVHSDGWT---CPTCQSQMPSQAALTKHRPVCE-------------------MTALYKPLMAQL 248

Human   461 SHANPGLADYFGANRHPAG---LTFPT-APGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQ 521
            :    ||:...|....|..   |...| ||.|..:|....|.. |........:||....||...
Worm   249 A----GLSGAGGLGSVPYWPHILQMATQAPHFPLAFLAANPEA-YKLMQQTTCASPDAECSSGHA 308

Human   522 TNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDV 586
            :  ..||..|.|..|.||.               ||
Worm   309 S--ESSPTTTEPVDLTATP---------------KP----------------------------- 327

Human   587 STPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEE 651
              ||.|::||||.||
Worm   328 --PSTSEMETTSKSD-------------------------------------------------- 340

Human   652 QTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDL 716
                .|...|||           |.:|.....|.:.|.|
Worm   341 ----DGEDRDSI-----------GDSGNDDDDDSEAGVL-------------------------- 364

Human   717 RSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSR 781
                                  .||....:||::        |:...::...:..|     :|::
Worm   365 ----------------------DESSTTTSTKKR--------PTSHTISDILAAPQ-----LGAQ 394

Human   782 SRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKE 846
            :           .|..|.|....::...||.        |:|                      .
Worm   395 A-----------LNSTFLGMLQRSLNYNPAV--------PSP----------------------H 418

Human   847 KYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALP 911
            .:||...|                                                  |..::.|
Worm   419 SFLRAMSG--------------------------------------------------AKASSSP 433

Human   912 ENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKE 976
            .:....||:||||::|.|:||||||||||||||||||||:|:||:|||||||||||||||||||.
Worm   434 SSSSGSGKDRYTCKFCQKVFPRSANLTRHLRTHTGEQPYKCQYCERSFSISSNLQRHVRNIHNKP 498

Human   977 K----PFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTG 1022
            .    |...|             |....|.:.:.|.|.|:..|..|...|
Worm   499 NTSLTPHNHH-------------RQRSLHNSTSTSTTTTTVHHPLLHLPG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MECOM	XP_005247270.1	PR-SET_PRDM3	47..204	CDD:380991
		C2H2 Zn finger	211..260	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368	7/18 (39%)
		zf-H2C2_2	277..301	CDD:372612	7/23 (30%)
		zf-C2H2	291..313	CDD:333835	5/21 (24%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..343	CDD:275368	2/21 (10%)
		zf-H2C2_2	334..360	CDD:372612	7/25 (28%)
		zf-C2H2	349..371	CDD:333835	12/21 (57%)
		C2H2 Zn finger	351..371	CDD:275368	11/19 (58%)
		zf-C2H2	377..399	CDD:333835	16/21 (76%)
		C2H2 Zn finger	379..399	CDD:275368	15/19 (79%)
		C2H2 Zn finger	408..426	CDD:275368	5/17 (29%)
		zf-C2H2	922..944	CDD:333835	17/21 (81%)
		C2H2 Zn finger	924..944	CDD:275368	15/19 (79%)
		zf-H2C2_2	936..960	CDD:372612	20/23 (87%)
		C2H2 Zn finger	952..973	CDD:275368	18/20 (90%)
		zf-H2C2_2	964..990	CDD:372612	14/29 (48%)
		C2H2 Zn finger	981..1001	CDD:275368	2/19 (11%)
egl-43	NP_001022288.1	SFP1	<115..210	CDD:227516	43/113 (38%)
		C2H2 Zn finger	161..181	CDD:275368	11/19 (58%)
		C2H2 Zn finger	189..209	CDD:275368	15/19 (79%)
		C2H2 Zn finger	215..232	CDD:275368	4/16 (25%)
		zf-C2H2	444..466	CDD:395048	17/21 (81%)
		C2H2 Zn finger	446..466	CDD:275368	15/19 (79%)
		zf-H2C2_2	458..482	CDD:404364	20/23 (87%)
		C2H2 Zn finger	474..495	CDD:275368	18/20 (90%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470824
Domainoid	1	1.000	52	1.000	Domainoid score	I8406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I2543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105951
Panther	1	1.100	-	-	LDO	PTHR24393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4598
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920