DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syne3 and Msp300

DIOPT Version :9

Sequence 1:	NP_001036164.1	Gene:	Syne3 / 212073	MGIID:	2442408	Length:	975	Species:	Mus musculus
Sequence 2:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster

Alignment Length:	1086	Identity:	232/1086 - (21%)
Similarity:	419/1086 - (38%)	Gaps:	254/1086 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 SVEDAQAWMKVIQEQLQVNDNTKGPRAALEARLRE-TEKICQLESEGMV--------KVELVLRA 67
            ||::....|::|:...||:          ..|||: ||::     ||:.        .::.:..|
  Fly 11976 SVQETDFMMELIRVHGQVD----------YERLRKATERL-----EGLAGDLHNREQLIDELKGA 12025

Mouse    68 AEALLATCQEGQKPEILARLRDIKSQWEETVTYMTHCHSRIEWVWLHWSEYLLAQDEFYRWF-QK 131
            |:.|:.:|......:|.:.:::....|.:|...:....:|.:.....|.:|..|........ |:
  Fly 12026 AKPLIESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRAVELWDKYRNASAAVKNSIDQQ 12090

Mouse   132 M--VVALEPPVELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAGSLFSRIGDPSVDEDAQ 194
            |  |.:||.|::          .|.||:|...|:..|.   ||:| |...:.::|. ..|..||.
  Fly 12091 MDAVKSLEQPLD----------ALQHAKVCQDNLTTQN---DRIL-ELRDIVAKIA-ADVGLDAS 12140

Mouse   195 KRMKAEYDAV---KARAQRRVDLLAQVAQDHEQYREDVNEFQLWLKAVVEKVHSCLGR----NCK 252
            ..|:.|.||:   .|..:..:..||.||:..::.|:::::.....||....|...:.|    |.|
  Fly 12141 ALMQGELDALGQRLAECKDAITTLANVAETQDKERKELDKEVTLAKAYFNNVQQDISREAPQNPK 12205

Mouse   253 LATELRLSTLQDIAKDFPRGEESLKRLEEQAVGVIQNTSPLGAEKISGELEEMRGVLEKLRVLWK 317
             .:|.:|:.|:...:...|.||.|::|:|:.    ||:..  |..::...::  |:||.| .||:
  Fly 12206 -ESEEQLAALRAHLQTLARTEEQLRQLKERH----QNSEV--APSVASSDDD--GILEVL-ALWQ 12260

Mouse   318 EEEGRLRGLLQSRGDCEQQIQQLEAELGDFKKSLQRLAQEGLEPTVKTATEDELVAQWRLF-SGT 381
            :       :.|   |..|:..:|...|                  .::....|.:..||.: ...
  Fly 12261 K-------IFQ---DTFQEYHRLSTRL------------------ARSQNSSEALRLWRQYLQHV 12297

Mouse   382 RAALASEEPR-VDRLQTQLKKLVTFPDLQSLSDSVVATI-------QEYQSMKGKNTRLHNATRA 438
            ::.|:...|. ...|:.|.:......:|.....||::..       ::|:::    |.|||.|.:
  Fly 12298 QSFLSCAIPEDYSSLREQQQLCAIHQNLLISQQSVLSETPLESELSEQYKAL----TNLHNETLS 12358

Mouse   439 ELWQRFQRPLNDLQLWKALAQRLLDITASLPD-------------LASIH------------TFL 478
            .:.||.......:..|.|..|:|    |:|.|             |..||            ..:
  Fly 12359 RIMQRNGELERRVSGWNAYRQQL----AALLDWLRQREAERNALQLRYIHLKRVPHLKHRLDAMI 12419

Mouse   479 PQIEAALTESSRLKEQ------------LAMLQLKTDLLGSIFGQERAAT-----LLEQVTSSVR 526
            .|::....:|..|:||            ...::::...:|......|||.     .|::||.
  Fly 12420 QQLDQGEQQSKALQEQQQELARHCDDALATAMRMEQASIGQRISNLRAALKTWQGFLQRVTQ--- 12481

Mouse   527 DRDLLHNSLLQRKSKLQSLLVQHKDFGVAFDPLNRKLLDLQARIQAEKGLPRDLPGKQVQLLRLQ 591
                |..|..||.::||      ::||.|     :||||..:         ..||.:...:.:|.
  Fly 12482 ----LSESYEQRVNQLQ------QEFGAA-----QKLLDANS---------ESLPTQPAAIEQLL 12522

Mouse   592 G-LQEEGLDLGTQIEAVRPLAHGN-------SKHQQKV----DQISCDQQA-LQRSLEDLVDRCQ 643
            | |:.:.:.||.|:.|:..|....       |.|..|.    :.:...|.| |...|.:|::..:
  Fly 12523 GSLRAQRVQLGAQVSALESLTVTQEELKECISPHDMKTIRQRNWLLWQQHADLDYQLANLINSIE 12587

Mouse   644 QNVREHCTFSHRLSELQLWITMATQTLESHQGDVRLWDAESQEAGLETLLS---EIPEKEVQVSL 705
            :.:.....:..|...:..|:....|.:|.......:.:.|.....||..::   ::.:|| :..|
  Fly 12588 ERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPEQAAKQLEQQVNSELQLRDKE-REWL 12651

Mouse   706 LQALGQLVMKKSSPEGATMVQEELRKLMESWQALRLLE--------ENMLSLMRNQQ-------- 754
            |....:|:...|.||..:.||::...|::.||.|:.|.        |..::|:|.::
  Fly 12652 LSTSRELLTLYSEPEVRSQVQQQSDSLIDRWQRLKYLAKQKATKIGELKMTLLRLEERIALIRAW 12716

Mouse   755 LQRTEVDTGKK---QVFTNNIPKAGFLINPQDPIPRRQHGANPLEGHDLPEDHPQLLRDFEQW-L 815
            |...|....|.   :.:|.|:.:|....:.|.......|.:|..|..:|.|   .||.|.:.| .
  Fly 12717 LFEVESQLDKPLNFESYTPNVIEAKLKEHEQIQRSIEHHSSNVGEVLNLVE---MLLNDADSWRT 12778

Mouse   816 QAENSKLRRIITMRVATAKDL--RTREVKLQ--ELEARIPEGQHLFENLLRLRP----------- 865
            |...|.|       .|:|::|  |.:.|..|  |.:|||....:|.:.|::|..
  Fly 12779 QVNTSGL-------AASAQNLEQRWKNVCSQSAERKARILTIWNLLQQLIKLTAEHKNWLGKQES 12836

Mouse   866 -----ARD-PSNELEDLRYRWMLYKSKLKDSGHLLTESSPGELTAFQKSRRQKRWSPCSLLQKAC 924
                 .|| .|:....|..|.|..::||::     .||....|...::...:...|.....:...
  Fly 12837 QIAGFERDQKSHSKHKLEERQMELRAKLEE-----LESQSVNLRQLEQIYAKLAMSAGVEPENIQ 12896

Mouse   925 RVALPLQLLLLLFLLLLFLLPAGEEERSCALANNFARSFALMLRYN 970
            ::.||.::::.::..|        ..|..||.:...:...||..:|
  Fly 12897 KLTLPTKVMVSMWRQL--------TPRCHALLDAIDKDAKLMREFN 12934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syne3	NP_001036164.1	SPEC	157..323	CDD:413338	45/172 (26%)
		Spectrin 1	220..325		25/108 (23%)
		SMC_prok_B	<296..>548	CDD:274008	57/302 (19%)
		SPEC	572..742	CDD:413338	39/185 (21%)
		Spectrin 2	647..740		20/95 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..798		4/19 (21%)
		KASH	<946..975	CDD:402255	6/25 (24%)
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705	12/46 (26%)
		SMC_prok_B	11614..12442	CDD:274008	116/541 (21%)
		SPEC	11994..12156	CDD:295325	42/191 (22%)
		SPEC	12374..12564	CDD:295325	48/220 (22%)
		Lipase_chap	12376..12529	CDD:281297	39/183 (21%)
		SPEC	12703..12923	CDD:238103	52/242 (21%)
		SPEC	12816..13032	CDD:295325	24/132 (18%)
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47535
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100