Protein Alignment ETV6 and aop

DIOPT Version :9

• Sequence 1: NP_001978.1
• Gene: ETV6 / 2120
• HGNCID: 3495
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_001259908.1
• Gene: aop / 33392
• FlyBaseID: FBgn0000097
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 138/511 - (27%)
• Similarity: 207/511 - (40%)
• Gaps: 114/511 - (22%)

Human     1 MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDD 65
            |...|.|.|:          .|..|...|......|...:.::.|...:||..|...|..|||:|
  Fly     4 MKMLPVQLSL----------NSLNPGIWSDVLWRCPPAPSSQLAELKTQLPPSLPSDPRLWSRED 58

Human    66 VAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQ------HILKQR 124
            |..:|::...||.|..:|.:.|:||||||.|||:.||.:|.|.:||||:.:||      |:::..
  Fly    59 VLVFLRFCVREFDLPKLDFDLFQMNGKALCLLTRADFGHRCPGAGDVLHNVLQMLIIESHMMQWH 123

Human   125 KP--------RILFSPFFHP-------------GNSIHTQPEVILHQNHEEDNCVQRTPRPSVDN 168
            .|        |...||..||             .:..|:....:...:....|.|..:|.||||:
  Fly   124 LPNSPVTPTSRYPLSPHSHPPTPTWPPLNAPPENSPFHSSAHSLAGHHFMAPNSVTLSPPPSVDS 188

Human   169 VHHNPPTIELLHRSRSPI----TTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQEN-- 227
            ...:||        ::|.    .|...|.......|......|.....|.:..:.|....|.|
  Fly   189 QASSPP--------QAPYQNGGATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSNGSQPNIM 245

Human   228 ----------NH---QESY-------------PLSVSPMENNHCP-----------------ASS 249
                      ||   :|.|             |||.|.......|                 .:|
  Fly   246 PMKGISSASSNHSDSEEEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNWTQQLTNSFVNS 310

Human   250 ESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSED-GLHREGKPI------NLS 307
            .|..:....:|::..|..:......|.|      ....:|.:|.:. .|.....|:      ::|
  Fly   311 WSQQQQQQQQQQAAAVAAVAAQAQQHQL------QQQQQQQQLPQKLTLDNTAGPVVTPAGGSIS 369

Human   308 HREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSD--SRYENFIRWEDKESKIFRI 370
            .....:||........|........|     |||||::.|||:|  .:|.:.|.|:.:::.:|:|
  Fly   370 APTTPSYMYKAKREFFPENSEPNTNG-----RLLWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKI 429

Human   371 VDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEI 426
            |||.|||:|||..||..:|.|:|||||||:||::||:||..|:|..::|::.|.|:
  Fly   430 VDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTEL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETV6	NP_001978.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		6/28 (21%)
		SAM_PNT-Tel_Yan	56..123	CDD:176085	32/72 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..262		29/152 (19%)
		ETS	338..424	CDD:197710	43/87 (49%)
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085	31/66 (47%)
		ETS	395..482	CDD:197710	44/91 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7419
eggNOG	1	0.900	-	-		E1_KOG3804
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4348
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D357152at33208
OrthoFinder	1	1.000	-	-		FOG0005558
OrthoInspector	1	1.000	-	-		otm41340
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4726
SonicParanoid	1	1.000	-	-		X5189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	11.050