DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETV4 and aop

DIOPT Version :9

Sequence 1:	NP_001073143.1	Gene:	ETV4 / 2118	HGNCID:	3493	Length:	484	Species:	Homo sapiens
Sequence 2:	NP_001259908.1	Gene:	aop / 33392	FlyBaseID:	FBgn0000097	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	135/563 - (23%)
Similarity:	189/563 - (33%)	Gaps:	197/563 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    45 LPPLDSEDLFQ------------DLSHFQETWLAEAQVPDSD------------EQFVPDFHSEN 85
            ||.||. ||||            |..|         :.|.:.            |..:..:|..|
  Fly    72 LPKLDF-DLFQMNGKALCLLTRADFGH---------RCPGAGDVLHNVLQMLIIESHMMQWHLPN 126

Human    86 LAFHSPTTRIKKEPQSPRTDPALSCSRKPPL-------PYHHGEQCLYSSAYDPPRQIAIKSP-- 141
                ||.|...:.|.||.:.|  .....|||       |:|.....|....:..|..:.:..|
  Fly   127 ----SPVTPTSRYPLSPHSHP--PTPTWPPLNAPPENSPFHSSAHSLAGHHFMAPNSVTLSPPPS 185

Human   142 ---------------------APGALGQSPLQPFPRAEQRNFLRSSGT------SQPH--PGHGY 177
                                 |||:.|.|...........|...||.:      |||:  |..|.
  Fly   186 VDSQASSPPQAPYQNGGATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSNGSQPNIMPMKGI 250

Human   178 ---LGEHSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEP---------CPPYPQQ------- 223
               ...||...::     :|.||.|..:.| |||..:..:.|         .|.:.||
  Fly   251 SSASSNHSDSEEE-----YSETSGGVSKMP-PAPLSYSTASPPGTPILKDIKPNWTQQLTNSFVN 309

Human   224 SFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGP 288
            |:.|:......:||...|........|:       ::|:|........:|        .:..:||
  Fly   310 SWSQQQQQQQQQQAAAVAAVAAQAQQHQ-------LQQQQQQQQLPQKLT--------LDNTAGP 359

Human   289 --SPGDGAM------GYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQ 345
              :|..|::      .|.| |..|.|                      |.|.......|.| ||.
  Fly   360 VVTPAGGSISAPTTPSYMY-KAKREF----------------------FPENSEPNTNGRL-LWD 400

Human   346 FLVALLDDPTNAH--FIAWTGR--GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKG 406
            ||..||:|....:  .|||..|  |: ||:::|..:|:|||||||..:|||||:||:|||||...
  Fly   401 FLQQLLNDRNQKYSDLIAWKCRDTGV-FKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVN 464

Human   407 IMQKVAGERYVYKFVCEPEALFSLA------------------------------------FPDN 435
            |::||.|||:.|:|:..|..|.::.                                    .|..
  Fly   465 ILRKVQGERHCYQFLRNPTELKNIKNISLLRQSTPANGNGGSPSMPQGSSQAPGSPAGQNWNPQQ 529

Human   436 QRPALKAEFDRPVSEEDTVPLSHLDESPAYLPELAGPAQPFGP 478
            |....:....||.|....:.|      ||.....|..|..:||
  Fly   530 QSQQQQQSPQRPASRNGPMSL------PAVAAVAAAAAAAYGP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETV4	NP_001073143.1	ETS_PEA3_N	8..339	CDD:309665	76/382 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..115		7/24 (29%)
		ETS	341..424	CDD:197710	44/86 (51%)
aop	NP_001259908.1	SAM_PNT-Tel_Yan	49..116	CDD:176085	11/53 (21%)
aop	NP_001259908.1	ETS	395..482	CDD:197710	45/88 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910