DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETFDH and CIR2

DIOPT Version :9

Sequence 1:	NP_004444.2	Gene:	ETFDH / 2110	HGNCID:	3483	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_015001.1	Gene:	CIR2 / 854538	SGDID:	S000005883	Length:	631	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	306/580 - (52%)
Similarity:	392/580 - (67%)	Gaps:	26/580 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    58 EGVNMERFAEEADVVIVGAGPAGLSAAVRLKQL-AVAHEKDIRVCLVEKAAQIGAHTLSGACLDP 121
            |.:|..|..:..||.|||.|||||:.|::|||| ..:....:||.::||::.:|..|:|||.|:|
Yeast    52 ELLNEPRARDYVDVCIVGGGPAGLATAIKLKQLDNSSGTGQLRVVVLEKSSVLGGQTVSGAILEP 116

Human   122 GAFKELFPDWK-EKGAP----LNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVS 181
            |.:||||||.| :.|.|    |.|.||::....|..|:.|.|| .|...:|...||||.|..:|.
Yeast   117 GVWKELFPDEKSDIGIPLPKELATLVTKEHLKFLKGKWAISVP-EPSQMINKGRNYIVSLNQVVG 180

Human   182 WMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAE 246
            ::||:||.:|||||||.|.:::::.::.:|||:.|.|.||.|.|.||.|||||:|..|:.|:.||
Yeast   181 YLGEKAEEVGVEVYPGIAVSDLIYDENNAVKGVITKDAGISKSGKPKETFERGMEFWARQTVLAE 245

Human   247 GCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYH 311
            ||||.|.||...|:|||...:.||||:|:||:|.:..:|:..|...||:|:||....|||.|.||
Yeast   246 GCHGSLTKQALAKYDLRKGRQHQTYGLGIKEVWEVKPENFNKGFAAHTMGYPLTNDVYGGGFQYH 310

Human   312 LNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPK 376
            ..:|  ||.:||||||||:|||:||::|||:.||||.....|||||.|||.||||||||.||:||
Yeast   311 FGDG--LVTVGLVVGLDYKNPYVSPYKEFQKMKHHPYYSKVLEGGKCIAYAARALNEGGLQSVPK 373

Human   377 LTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTS----ENLQ---------SKTI 428
            |.||||:|:|.|.||||||||||||||||||:|||||||..:..    |.::         .|..
Yeast   374 LNFPGGVLVGASAGFMNVPKIKGTHTAMKSGLLAAESIFESIKGLPVLEEVEDEDAKMAMFDKEA 438

Human   429 GLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLK-HKGSD 492
            .:::..||...|.|.::||||.|||||||..|.||.||||||:||...||:|..||||| .:.:|
Yeast   439 TINLESYESAFKESSIYKELYEVRNIRPSFSGKLGGYGGMIYSGIDSLILKGKVPWTLKFDEKND 503

Human   493 FERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTL--RDDSIPVNRNLSIYDG 555
            .|.|:||....|||||||||.||||:|:||:.:||.|:.|:|.||.:  :|......|:..::.|
Yeast   504 GEILEPASKYKPIEYPKPDGVISFDILTSVSRTGTYHDDDEPCHLRVPGQDMVKYAERSFPVWKG 568

Human   556 PEQRFCPAGVYEFVPVEQGD-GFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAY 614
            .|.|||||||||||..|:.. |.|||||:|||:||||||||.|.|:|.|.|||||.||.|
Yeast   569 VESRFCPAGVYEFVKDEKSPVGTRLQINSQNCIHCKTCDIKAPRQDITWKVPEGGDGPKY 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	253/481 (53%)
		NADB_Rossmann	68..>217	CDD:304358	68/154 (44%)
		ETF_QO	512..615	CDD:282972	60/106 (57%)
CIR2	NP_015001.1	NADB_Rossmann	46..>78	CDD:419666	13/25 (52%)
		FixC	63..540	CDD:223717	253/479 (53%)
		ETF_QO	523..629	CDD:398727	60/106 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159051339
Domainoid	1	1.000	409	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	580	1.000	Inparanoid score	I169
Isobase	1	0.950	-	0	Normalized mean entropy	S422
OMA	1	1.010	-	-		QHG54178
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto145390
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740