DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETFDH and etfdh

DIOPT Version :9

Sequence 1:	NP_004444.2	Gene:	ETFDH / 2110	HGNCID:	3483	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_001004598.1	Gene:	etfdh / 447859	ZFINID:	ZDB-GENE-040912-168	Length:	617	Species:	Danio rerio

Alignment Length:	619	Identity:	496/619 - (80%)
Similarity:	558/619 - (90%)	Gaps:	5/619 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     2 LVPLAKLSCLAYQCFHALKIKK--NYLP-LCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNME 63
            ::|.::.:..|.:|.||||:.|  :..| :.:|||  .|:|||||||||:||||||.|||||.||
Zfish     1 MLPASRYTLQARRCIHALKVVKAEHVAPQIYSTRW--FSSVPRITTHYTVYPRDKDSRWEGVEME 63

Human    64 RFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELF 128
            |||:||||||:|.||||||||:||||||..|||::|||:||||:||||||||||||:|.|..||.
Zfish    64 RFADEADVVIIGGGPAGLSAAIRLKQLANQHEKELRVCVVEKASQIGAHTLSGACLEPTALNELI 128

Human   129 PDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVE 193
            |||||:|||||||||||:|.||||||||||||||||||||||||:|||||.|.|:|||||.||||
Zfish   129 PDWKERGAPLNTPVTEDKFSILTEKYRIPVPILPGLPMNNHGNYLVRLGHFVRWLGEQAEELGVE 193

Human   194 VYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYK 258
            :||||||||||||:||||||||||||||.|||:||..||||:|||||||:|.|||||||||||||
Zfish   194 LYPGYAAAEVLFHEDGSVKGIATNDVGIAKDGSPKDVFERGMELHAKVTMFGEGCHGHLAKQLYK 258

Human   259 KFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGL 323
            :|:||..||||||.||||||||||||.|:|||.:|:|||||:|:||||:|||||||||||||||.
Zfish   259 QFNLREKCEPQTYAIGLKELWVIDEKKWRPGRAEHSVGWPLNRNTYGGTFLYHLNEGEPLVALGF 323

Human   324 VVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIGCS 388
            ||||||.|||:||||||||||||||:..|||||.||||||||||||||||||:||||||:|||||
Zfish   324 VVGLDYTNPYMSPFREFQRWKHHPSVMSTLEGGNRIAYGARALNEGGFQSIPQLTFPGGMLIGCS 388

Human   389 PGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRN 453
            |||||||||||||||||||:||||:.|:::|.|||||:|.||::.|||:.||.|||||||.||||
Zfish   389 PGFMNVPKIKGTHTAMKSGMLAAETAFSKITDENLQSQTTGLYIPEYEEALKKSWVWKELRSVRN 453

Human   454 IRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDL 518
            ||||.|...|:||||:||||||||.||.|||||||.|||:.:|||||||:|||||||||:|||||
Zfish   454 IRPSFHTYFGLYGGMVYTGIFYWIFRGKEPWTLKHSGSDYAQLKPAKDCSPIEYPKPDGKISFDL 518

Human   519 LSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINA 583
            |||||||||||||||||||||:||||||::||:||||||||||||||||:||:|.|||.||||||
Zfish   519 LSSVALSGTNHEHDQPAHLTLKDDSIPVSKNLAIYDGPEQRFCPAGVYEYVPLETGDGMRLQINA 583

Human   584 QNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM 617
            |||||||||||||||||||||||||.||||||||
Zfish   584 QNCVHCKTCDIKDPSQNINWVVPEGSGGPAYNGM 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	377/461 (82%)
		NADB_Rossmann	68..>217	CDD:304358	124/148 (84%)
		ETF_QO	512..615	CDD:282972	92/102 (90%)
etfdh	NP_001004598.1	FixC	67..529	CDD:223717	377/461 (82%)
		NADB_Rossmann	73..>199	CDD:304358	102/125 (82%)
		ETF_QO	512..615	CDD:282972	92/102 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339791
Domainoid	1	1.000	690	1.000	Domainoid score	I1183
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I2019
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54178
OrthoDB	1	1.010	-	-		D117499at7742
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto46628
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300