Protein Alignment ETFDH and Etf-QO

DIOPT Version :9

• Sequence 1: NP_004444.2
• Gene: ETFDH / 2110
• HGNCID: 3483
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_001246231.1
• Gene: Etf-QO / 36031
• FlyBaseID: FBgn0286783
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 396/599 - (66%)
• Similarity: 479/599 - (79%)
• Gaps: 4/599 - (0%)

Human    20 KIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAA 84
            ::::.:.|..|...|..:..||||||||:.||:||:||..|:|||..||.|:||||.||||:|||
  Fly     9 RVRRLFSPALARSISDVAKYPRITTHYTLNPREKDERWTEVDMERCVEEVDLVIVGGGPAGMSAA 73

Human    85 VRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGI 149
            :|.||||...:::||||:|||||::|.|.||||.:||.:..||.|||:|:|||||||||:|.|..
  Fly    74 IRAKQLAAEKDQEIRVCVVEKAAEVGGHILSGAVIDPISLNELIPDWQEQGAPLNTPVTKDTFSF 138

Human   150 LTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGI 214
            ||...||.:|:..|.||:|||||:|||||||.|:|:||||||||:|||.||:|||||:|||||||
  Fly   139 LTGSGRISIPVFKGWPMDNHGNYVVRLGHLVKWLGDQAEALGVEIYPGCAASEVLFHEDGSVKGI 203

Human   215 ATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELW 279
            |||||||.|.||||.||.||:|||||.|||||||.|||.||:.:||.|....|||.|||||||:|
  Fly   204 ATNDVGIAKSGAPKDTFARGMELHAKTTIFAEGCRGHLTKQIMQKFGLNEGSEPQAYGIGLKEVW 268

Human   280 VIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWK 344
            .|..:..:||.|:||:||||||.||||||||||||..|.:|:|.||||:|:||:||||:||||:|
  Fly   269 EIAPEKHQPGLVEHTIGWPLDRFTYGGSFLYHLNEPTPTIAVGFVVGLNYKNPWLSPFQEFQRFK 333

Human   345 HHPSIRPTLEGGKRIAYGARALNEGGFQSIP-KLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGI 408
            .||.:|...||..||||||||:|||||||:| ||:||||.|:|||.||:|||:|||:|.|||||:
  Fly   334 THPKVRDVFEGATRIAYGARAINEGGFQSLPQKLSFPGGCLVGCSAGFLNVPRIKGSHYAMKSGM 398

Human   409 LAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGI 473
            |||||.|..:.::  ...|.|:..|.|.:.:|:|:|||:||||||:.||.|..||:|||::.:|
  Fly   399 LAAESAFEAINAD--AQSTAGVEPTGYAEKIKDSFVWKDLYSVRNVHPSFHNPLGLYGGLVLSG- 460

Human   474 FYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLT 538
            |...:.|.|||||||...|.|.||||..|.||.||||||:|||||||||||:|||||.|||||||
  Fly   461 FSIFMGGREPWTLKHGPQDHESLKPASSCPPIVYPKPDGKISFDLLSSVALTGTNHEGDQPAHLT 525

Human   539 LRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQNINW 603
            |:||.|||:.||::|:|||||||||||||:||.|:|...:||||||||:||||||||||.|||||
  Fly   526 LKDDRIPVDHNLALYEGPEQRFCPAGVYEYVPNEEGGNMKLQINAQNCIHCKTCDIKDPKQNINW 590

Human   604 VVPEGGGGPAYNGM 617
            ||||||||||||||
  Fly   591 VVPEGGGGPAYNGM 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	302/462 (65%)
		NADB_Rossmann	68..>217	CDD:304358	100/148 (68%)
		ETF_QO	512..615	CDD:282972	83/102 (81%)
Etf-QO	NP_001246231.1	NADB_Rossmann	44..>206	CDD:304358	107/161 (66%)
		FixC	56..516	CDD:223717	302/462 (65%)
		ETF_QO	499..602	CDD:282972	83/102 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158659
Domainoid	1	1.000	542	1.000	Domainoid score	I265
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	849	1.000	Inparanoid score	I438
Isobase	1	0.950	-	0	Normalized mean entropy	S422
OMA	1	1.010	-	-		QHG54178
OrthoDB	1	1.010	-	-		D180808at33208
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto91341
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750