DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETFDH and Etfdh

DIOPT Version :9

Sequence 1:	NP_004444.2	Gene:	ETFDH / 2110	HGNCID:	3483	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_942037.2	Gene:	Etfdh / 295143	RGDID:	735052	Length:	616	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	576/617 - (93%)
Similarity:	593/617 - (96%)	Gaps:	1/617 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERF 65
            |||.|.||||.|||.|||||||| .|||||.|.||||.||:|||||||:||:|||||||||||||
  Rat     1 MLVRLTKLSCPAYQWFHALKIKK-CLPLCAPRCSSTSAVPQITTHYTIHPREKDKRWEGVNMERF 64

Human    66 AEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPD 130
            |||||||||||||||||||:||||||...|||||||||||||||||||||||||||.||||||||
  Rat    65 AEEADVVIVGAGPAGLSAAIRLKQLAAEQEKDIRVCLVEKAAQIGAHTLSGACLDPAAFKELFPD 129

Human   131 WKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVY 195
            |||||||||||||||||.|||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   130 WKEKGAPLNTPVTEDRFAILTEKHRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVY 194

Human   196 PGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKF 260
            |||||||||:|:|||||||||||||||||||||.|||||||||||||||||||||||||||||||
  Rat   195 PGYAAAEVLYHEDGSVKGIATNDVGIQKDGAPKTTFERGLELHAKVTIFAEGCHGHLAKQLYKKF 259

Human   261 DLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVV 325
            ||||:|:.||||||||||||||||.|||||||||||||||||||||||||||||||||||:|.||
  Rat   260 DLRASCDAQTYGIGLKELWVIDEKKWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVAVGFVV 324

Human   326 GLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIGCSPG 390
            |||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||
  Rat   325 GLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGLQSIPKLTFPGGLLIGCSPG 389

Human   391 FMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIR 455
            |||||||||||||||||.||||:||.|||||||||||.||||||||||||.|||||||::|||||
  Rat   390 FMNVPKIKGTHTAMKSGSLAAEAIFKQLTSENLQSKTAGLHVTEYEDNLKQSWVWKELHAVRNIR 454

Human   456 PSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLS 520
            |||||:|||||||||||||||||||||||||||||||.|:|||||||||||||||||||||||||
  Rat   455 PSCHGILGVYGGMIYTGIFYWILRGMEPWTLKHKGSDSEQLKPAKDCTPIEYPKPDGQISFDLLS 519

Human   521 SVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQN 585
            |||||||||||||||||||:||||||||||||||||||||||||||||||:||||||||||||||
  Rat   520 SVALSGTNHEHDQPAHLTLKDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPLEQGDGFRLQINAQN 584

Human   586 CVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM 617
            ||||||||||||||||||||||||||||||||
  Rat   585 CVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	434/461 (94%)
		NADB_Rossmann	68..>217	CDD:304358	139/148 (94%)
		ETF_QO	512..615	CDD:282972	100/102 (98%)
Etfdh	NP_942037.2	FixC	66..528	CDD:223717	434/461 (94%)
		NADB_Rossmann	67..>261	CDD:304358	183/193 (95%)
		ETF_QO	511..614	CDD:282972	100/102 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83692004
Domainoid	1	1.000	794	1.000	Domainoid score	I2711
eggNOG	1	0.900	-	-		E1_COG2440
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	1206	1.000	Inparanoid score	I4044
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54178
OrthoDB	1	1.010	-	-		D117499at7742
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto137731
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270