DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETFDH and SPAC20G8.04c

DIOPT Version :9

Sequence 1:	NP_004444.2	Gene:	ETFDH / 2110	HGNCID:	3483	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_593321.1	Gene:	SPAC20G8.04c / 2541985	PomBaseID:	SPAC20G8.04c	Length:	632	Species:	Schizosaccharomyces pombe

Alignment Length:	622	Identity:	316/622 - (50%)
Similarity:	409/622 - (65%)	Gaps:	36/622 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     2 LVPLAKLSCLAYQCFHALKI-----KKNYLPLCATRWSSTST-VPRITTHYTIYPRDKDKRWEGV 60
            ::|||..|.|       |||     ::::..|.|..:.|:|. :..:|.:.    |..|
pombe    35 VLPLASPSTL-------LKISSQTLRQDFTVLGARNFHSSSVRLNELTDNL----RKLD------ 82

Human    61 NMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFK 125
            .:||..|:.||.||||||||||||:|:||.|....:||||.::||||:.|.|::|||.:.|.|..
pombe    83 TIEREVEDVDVCIVGAGPAGLSAAIRIKQQAAKANRDIRVVVLEKAAEPGNHSVSGAVIQPTALD 147

Human   126 ELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEAL 190
            ||.|:|::......|.||.|:...|..|...|:|:.|.  |.|||||::.|.....|:..:||..
pombe   148 ELLPNWRDDPPENCTAVTHDKMKFLIPKLHFPIPVPPA--MKNHGNYVMSLAEFTRWLAAKAEEY 210

Human   191 GVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQ 255
            |||:||.:||:|||::.||||.|:||||.|:...|.||..||||:..||.||:||||.||.|:|.
pombe   211 GVEIYPSFAASEVLYNKDGSVIGVATNDFGVDSKGLPKDNFERGMAFHAPVTLFAEGAHGSLSKS 275

Human   256 LYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVA 320
            :.|:|:||.||||||||:|:||:|.:.::|::.|.|.||:|||:...||||.|:|..  |:..|.
pombe   276 IIKRFNLRGNCEPQTYGLGVKEVWRVPDENFRKGEVAHTLGWPMRNDTYGGGFMYQF--GDNYVT 338

Human   321 LGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLI 385
            :||||||||.|||:||..||||.|.:|.....|:|||.:.|.||||||||:|:||||.||||.||
pombe   339 VGLVVGLDYPNPYVSPALEFQRMKQNPFFAKVLKGGKCLEYAARALNEGGYQAIPKLVFPGGALI 403

Human   386 GCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYS 450
            |||.||:||.|||||||||||||:||::|.:.. ..:..||.:.|:  :||:||||::|:|||||
pombe   404 GCSAGFVNVAKIKGTHTAMKSGIVAADAIVDAF-GRDAASKPLLLN--DYEENLKNTYVFKELYS 465

Human   451 VRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQIS 515
            |||||||.|..||.||||.|:.:..::|:|..||||||||.|.:..|.|....||.|||||..:|
pombe   466 VRNIRPSFHSFLGNYGGMAYSAVEAYVLKGRVPWTLKHKGGDAKATKSASKYKPINYPKPDNVLS 530

Human   516 FDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRN--LSIYDGPEQRFCPAGVYEFVPVEQGD-GF 577
            ||:.:||:.|.|.|..:||.||.   |..|.:|.  ...|.|.|.:||||||||:|..|... |.
pombe   531 FDIPTSVSRSATMHAENQPCHLF---DHRPKDRKSCFETYKGVENKFCPAGVYEYVNDEASSYGK 592

Human   578 RLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAY 614
            |..||:||||||||||||||.|.|.|..|:||.||.|
pombe   593 RFVINSQNCVHCKTCDIKDPLQGIQWKTPQGGDGPKY 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	251/461 (54%)
		NADB_Rossmann	68..>217	CDD:304358	72/148 (49%)
		ETF_QO	512..615	CDD:282972	55/106 (52%)
SPAC20G8.04c	NP_593321.1	FadH2	<44..>132	CDD:223523	40/104 (38%)
		FixC	89..544	CDD:223717	251/461 (54%)
		NADB_Rossmann	92..469	CDD:304358	210/383 (55%)
		ETF_QO	527..630	CDD:282972	55/106 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	442	1.000	Domainoid score	I85
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	603	1.000	Inparanoid score	I182
OMA	1	1.010	-	-		QHG54178
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto146925
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860