DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETFDH and let-721

DIOPT Version :9

Sequence 1:	NP_004444.2	Gene:	ETFDH / 2110	HGNCID:	3483	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_001379625.1	Gene:	let-721 / 175916	WormBaseID:	WBGene00002855	Length:	597	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	364/577 - (63%)
Similarity:	449/577 - (77%)	Gaps:	6/577 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    43 TTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAA 107
            |||||:..|..|.||:.|::.|.::..||||||.||:|||||:||:|||...:|::|||:||||:
Worm    25 TTHYTVKDRSTDPRWKDVDLARESDVYDVVIVGGGPSGLSAAIRLRQLAEKAQKELRVCVVEKAS 89

Human   108 QIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNY 172
            .||.||||||.::..|..||.|:|||.|||:...||.:...||||..|||||:|||:|:.|||||
Worm    90 VIGGHTLSGAVIETRALDELIPNWKELGAPVYQQVTSESIAILTESGRIPVPVLPGVPLANHGNY 154

Human   173 IVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLEL 237
            |||||.:|.|:||||||.||||:|..||:|||:::|||||||||:||||.||||||..|.||:|.
Worm   155 IVRLGKVVQWLGEQAEAAGVEVWPEIAASEVLYNEDGSVKGIATSDVGIGKDGAPKDGFARGMEF 219

Human   238 HAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRH 302
            |||.|||||||.|||:||:..|||||.:.  .||||||||||.||....:||.|:||:||||:..
Worm   220 HAKCTIFAEGCRGHLSKQVLDKFDLRTHA--MTYGIGLKELWEIDPAKHRPGYVEHTMGWPLNVD 282

Human   303 TYGGSFLYHL-NEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARAL 366
            .||||||||: ::|:|||::|.||.|||.||.|:|::|||::|.||||...|||||||.||||||
Worm   283 QYGGSFLYHIEDQGQPLVSVGFVVALDYANPNLNPYKEFQKYKTHPSISKQLEGGKRIGYGARAL 347

Human   367 NEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLH 431
            |||||||||||.||||.|:|||.||:||.|:||||.|||||::||||||..:..:....:||  .
Worm   348 NEGGFQSIPKLHFPGGCLVGCSAGFLNVAKLKGTHNAMKSGMVAAESIFEDIQQKGEDVQTI--D 410

Human   432 VTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERL 496
            ...|:.|:::::|.|||.:.||||||.:..||..||:||:||||...||:|||||.|...|.|:|
Worm   411 PATYDKNIRDTYVVKELKATRNIRPSFNTSLGYIGGLIYSGIFYVFGRGIEPWTLGHGKKDNEKL 475

Human   497 KPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFC 561
            .|.||...|:||||||:::||||:||:|:||||..||||||||::|.:|::.||::|.|||.|||
Worm   476 IPVKDAKEIDYPKPDGKLTFDLLTSVSLTGTNHTEDQPAHLTLKNDQVPLDVNLAVYGGPEARFC 540

Human   562 PAGVYEFVPVEQGDG-FRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM 617
            |||||||||.|..:. .|||||||||:||||||||||.||||||.|||||||.|.||
Worm   541 PAGVYEFVPSEADESKKRLQINAQNCIHCKTCDIKDPQQNINWVTPEGGGGPKYEGM 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETFDH	NP_004444.2	FixC	67..529	CDD:223717	287/462 (62%)
		NADB_Rossmann	68..>217	CDD:304358	95/148 (64%)
		ETF_QO	512..615	CDD:282972	73/103 (71%)
let-721	NP_001379625.1	FixC	48..508	CDD:223717	287/463 (62%)
let-721	NP_001379625.1	ETF_QO	491..594	CDD:398727	73/102 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470805
Domainoid	1	1.000	494	1.000	Domainoid score	I195
eggNOG	1	0.900	-	-		E1_COG2440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3275
Inparanoid	1	1.050	752	1.000	Inparanoid score	I330
Isobase	1	0.950	-	0	Normalized mean entropy	S422
OMA	1	1.010	-	-		QHG54178
OrthoDB	1	1.010	-	-		D180808at33208
OrthoFinder	1	1.000	-	-		FOG0003019
OrthoInspector	1	1.000	-	-		oto21118
orthoMCL	1	0.900	-	-		OOG6_101719
Panther	1	1.100	-	-	LDO	PTHR10617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R420
SonicParanoid	1	1.000	-	-		X3366
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790