Protein Alignment ETF1 and eRF1

DIOPT Version :10

• Sequence 1: NP_004721.1
• Gene: ETF1 / 2107
• HGNCID: 3477
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001262105.1
• Gene: eRF1 / 40240
• FlyBaseID: FBgn0036974
• Length: 447
• Species: Drosophila melanogaster
• Alignment Length: 415
• Identity: 359/415 - (86%)
• Similarity: 384/415 - (92%)
• Gaps: 3/415 - (0%)

Human     1 MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSR 65
            |:.:.::||||||||||||||||||.||||||||||||||||||||||:||||||||||||||||
  Fly     1 MSGEETSADRNVEIWKIKKLIKSLEMARGNGTSMISLIIPPKDQISRVSKMLADEFGTASNIKSR 65

Human    66 VNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNK 130
            ||||||||||||||.|||||.||||||||:|||||||||||||||||||||||||||||||||||
  Fly    66 VNRLSVLGAITSVQHRLKLYTKVPPNGLVIYCGTIVTEEGKEKKVNIDFEPFKPINTSLYLCDNK 130

Human   131 FHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRM 195
            ||||||||||:||:||||||:||:|||||||||||||||||||||||||||||||||||||||||
  Fly   131 FHTEALTALLADDNKFGFIVMDGNGALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRM 195

Human   196 EKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGG 260
            ||||||||||||.|.||||:.||.|:|||:||||||||||||||||||.||||||:||||:||||
  Fly   196 EKRHNYVRKVAEVATQLFITNDKPNIAGLILAGSADFKTELSQSDMFDPRLQSKVIKLVDVSYGG 260

Human   261 ENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYEN 325
            ||||||||||:.|.|.|||||||||||||||||||||||||||||||||:|||:|:||.||.:||
  Fly   261 ENGFNQAIELAAESLQNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLRALELGSVETLICWEN 325

Human   326 LDIMRYVL--HCQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGAT 388
            |||.||||  |...| ...:|:||||||||||||||||:|.|.|||||.|||||.|||||.||||
  Fly   326 LDIQRYVLKNHANST-STTVLHLTPEQEKDKSHFTDKESGVEMELIESQPLLEWLANNYKMFGAT 389

Human   389 LEIVTDKSQEGSQFVKGFGGIGGIL 413
            |||:|||||||||||:|||||||.|
  Fly   390 LEIITDKSQEGSQFVRGFGGIGGTL 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETF1	NP_004721.1	aRF1/eRF1	13..417	CDD:274719	353/403 (88%)
		NIKS motif, plays an important role in translational termination. /evidence=ECO:0000305|PubMed:24486019	61..64		2/2 (100%)
eRF1	NP_001262105.1	aRF1/eRF1	13..414	CDD:274719	352/401 (88%)