Protein Alignment ESRRG and nhr-146

DIOPT Version :10

• Sequence 1: XP_011507567.1
• Gene: ESRRG / 2104
• HGNCID: 3474
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_001122810.1
• Gene: nhr-146 / 6418682
• WormBaseID: WBGene00045255
• Length: 365
• Species: Caenorhabditis elegans
• Alignment Length: 354
• Identity: 90/354 - (25%)
• Similarity: 156/354 - (44%)
• Gaps: 62/354 - (17%)

Human   140 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC--PATNECEITKRRRKSCQACRFMKCLK 202
            |.||..:::|:|:||..|.||.|||:||:.....:.|  ...|.|||.......|::|||.|||.
 Worm     5 CPVCQALSNGFHFGVEVCSACSAFFRRTVFKKRNFRCWGEPVNCCEIVSTGSAFCKSCRFAKCLA 69

Human   203 VGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEK 267
            |||.||     .|:.||:.|.:| :....|.::.........|:|.:......::.::.:.
 Worm    70 VGMKKE-----TVQQGREGYGKR-EMALVPVISKFKANRQGLPILETIVETYSLLLNVRIC---- 124

Human   268 IYAMPD-PTVPDSDIKAL----TTLCDLADRELVVIIGWAKH-IPGFSTLSLADQMSLL-QSAWM 325
            ::..|: ...|..|.|.:    |..|.|  :|..::..|..| .|.|:...: ||..|| ::.::
 Worm   125 VHEGPNGSNSPKRDPKPVNYKETIACFL--KEFYLVGDWLSHCFPEFAAFPV-DQKDLLHRNFYL 186

Human   326 EILIL-GVVY---------RSLSFED--ELVYADDYIMDED--QSKLAGLLDLNNAILQLVKKYK 376
            :.::| |..:         |.|...|  :.|..:.|..|.|  |....|     .|:......::
 Worm   187 QFVVLEGGFFSCNHKRSDIRYLPSGDYIDCVNPETYYYDPDGKQPMTPG-----EAVTLFASSFQ 246

Human   377 SMK-----------LEKEEFVTLKAIALANSDSMHI-EDVEAV-----QKLQDVLHEALQDYEAG 424
            |.:           .::.||:.|..:||.::|..:| |:..||     ||:|   ...|:.|.:.
 Worm   247 SYRRNVTHPMLRENADRFEFLALTGLALFDADLENISEETAAVCRKVRQKIQ---RNMLKYYIST 308

Human   425 QHMEDPR-RAGKMLMTLPLLRQTSTKAVQ 452
            :..||.. |.|.::..:|.|.:.:.:.::
 Worm   309 KSPEDASVRLGNLISIIPSLHRATRRFLE 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESRRG	XP_011507567.1	NR_DBD_ERR	134..230	CDD:143544	37/91 (41%)
		NR_LBD_ERR	256..475	CDD:132744	50/236 (21%)
nhr-146	NP_001122810.1	ZnF_C4	4..75	CDD:197701	30/69 (43%)
		Hormone_recep	132..331	CDD:459675	49/209 (23%)